Diacerein (INN), also known as diacetylrhein, is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. [1] . It works by inhibiting interleukin-1 beta. An updated 2014 Cochrane review found diacerein had a small beneficial effect on pain. [2] .

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling.

2016年10月20日 · Diacerein is an slow-onset anthraquinone IL-1 inhibitor used in the treatment of degenerative joint diseases like osteoarthritis. Diacerein is a prodrug which is metabolized to rhein.

2020年11月1日 · Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) and the active metabolite is rhein. It is a non-steroidal anti-inflammatory drug with unique pharmacological properties as anti-oxidant and anti-apoptosis.

Diacerein is a slow-acting drug taken as a pill that may slow the breakdown of cartilage and relieve pain and swelling. The review searched for studies up to March 2013 about primary osteoarthritis affecting men and women (18 years and older) of any disease severity. The review shows that in people with osteoarthitis:

We systematically reviewed the efficacy, safety, and residual effectiveness of diacerein. To estimate the symptomatic efficacy, residual effect and safety of diacerein in the treatment of knee osteoarthritis, using a meta-analysis of published randomized controlled trials (RCTs).

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling.

2020年2月27日 · Diacereína es un medicamento con propiedades analgésicas empleado para tratar las enfermedades degenerativas que atacan las articulaciones. Tiene como principio activo un compuesto con el mismo nombre cuyo efecto es hidratar y nutrir el cartílago de las articulaciones. Asimismo, bloquea las sustancias que causan dolor e inflamación.

La diacereína es un medicamento indicado para el tratamiento de las osteoartritis, ya que tiene propiedades antiosteoartrósicas, mejorando la composición de las articulaciones e impidiendo la degradación del cartílago, además de tener efectos antiinflamatorios y analgésicos.

2025年1月7日 · Diacerein is a slow-acting medicine of the class anthraquinone used to treat joint diseases such as osteoarthritis. How safe is Diacerein? Diacerein is safe, apart from a substantially higher risk of diarrhoea, especially with longer-term use.Diacerein has an acceptable safety profile, particularly in comparison with that of NSAIDs and paracetamol.