DiaPep277® is a small, lyophilized powder containing 24 Amino-acids. We have proved in former studies that DiaPep277® can slow down beta cells destruction in the pancreas and therefore decelerate the progress of Diabetes. The objective of the study is to assess the efficacy and safety of administrating DiaPep277® in type 1 diabetes patients.

Background: Treatment with DiaPep277, a peptide derived from HSP60, has been shown to preserve beta-cell function in non-obese diabetic mouse (NOD) mice and in a trial with newly diagnosed human patients with type 1 diabetes treated over a 10-month period.

DiaPep 277 | C106H180N28O34 | CID 16138701 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2008年3月19日 · DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60 (437-460). The next evolution of DrugBank is here. Designed for scientists, driven by AI, and powered by real-time insights. This is drug intelligence, redefined. Investigated for use/treatment in diabetes mellitus type 1, autoimmune diseases, and diabetes mellitus type 2.

DiaPep277 is a 24 amino acid peptide derived from positions 437-460 in HSP60. DiaPep277 arrests the progression of β-cell destruction in NOD mice. DiaPep277 has an immune modulatory effect on diabetogenic T cells in animal models of diabetes [1] [2].

DiaPep277, a major T-cell epitope of heat shock protein 60 (hsp60), has been shown to be effective in the modulation of the immune response in recent onset T1D and is the main focus of this review in the context of other ongoing trials using different approaches.

However, thus far no immune-based therapeutic regimen has cured type 1 diabetes after its clinical onset or has stabilized the decline of C-peptide to achieve the status of an approved drug. This review summarizes immune intervention trials and the current knowledge of DiaPep277® peptide as a form of immune intervention in type 1 diabetes.

2025年1月7日 · DiaPep 277 is a 24-mer laboratory-made peptide derived from Hsp60 (437-460). Investigated for use/treatment in diabetes mellitus type 1, autoimmune diseases, and diabetes mellitus type 2. *** Taking medicines without doctor's advice can cause long-term problems. Learn about DiaPep 277 uses, dosage, side effects, food interactions, and more.

2014年4月10日 · DiaPep277 is a 24 amino-acid peptide derived from human heat-shock protein 60 that has been demonstrated to modulate immunological attack on β-cells in the NOD mouse model of type 1 diabetes (18, 19).