2020年5月19日 · Among the top candidates, 2,4-dienoyl-CoA reductase (DECR1), a mitochondrial enzyme involved in polyunsaturated fatty acid (PUFA) degradation, represents a potential therapeutic target for CRPC....

2,4 Dienoyl-CoA reductase also known as DECR1 is an enzyme which in humans is encoded by the DECR1 gene which resides on chromosome 8. This enzyme catalyzes the following reactions [1] [2] [3] DECR1 participates in the beta oxidation and metabolism of …

2019年8月19日 · To shed light on PUFA physiology, we have generated a mouse line defective in mitochondrial dienoyl-CoA reductase (Decr), which is a key enzyme required for β-oxidation of PUFAs.

2024年12月24日 · DECR1 (2,4-Dienoyl-CoA Reductase 1) is a Protein Coding gene. Diseases associated with DECR1 include 2,4-Dienoyl-Coa Reductase Deficiency and Hyperlysinemia. Among its related pathways are Metabolism and Fatty acid metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and NADPH binding.

2012年8月8日 · Here, we describe the crystal structure of a ternary complex of peroxisomal 2,4-dienoyl CoA reductases (pDCR) with hexadienoyl CoA and NADP, as a prototype for comparison with the mitochondrial 2,4-dienoyl CoA reductase (mDCR) to shed light on the differences between the enzymes from the two organelles at the molecular level.

2001年8月29日 · Kinetic analysis of recombinant human peroxisomal dienoyl-CoA reductase. In panels A–C, the reductase activity of purified His-tagged human pDCR protein was analyzed versus increasing concentrations of different 2,4-dienoyl-CoAs in the presence of 0.1% (w/v) albumin (closed symbols) or in the absence of albumin (open symbols).

2020年5月19日 · Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased characterisation of LNCaP cells chronically exposed to multiple AR inhibitors (ARI).

However, many aspects on signals translating PUFA-sensing into body homeostasis have remained enigmatic. To shed light on PUFA physiology, we have generated a mouse line defective in mitochondrial dienoyl-CoA reductase (Decr), which is a key enzyme required for β-oxidation of PUFAs.

2006年12月1日 · The mammalian peroxisomal MFE-1 catalyzes, among the other isomerase reactions, the conversion of 2E,5Z-dienoyl-CoA into 3E,5Z-dienoyl-CoA. The product is a substrate for dienoyl-CoA isomerase and thus the participation in dienoyl-CoA isomerase-dependent degradation of (poly)unsaturated fatty acids has been proposed in vivo function of ...

2005年1月28日 · We present high resolution crystal structures of human mitochondrial 2,4-dienoyl-CoA reductase in binary complex with cofactor, and the ternary complex with NADP + and substrate trans-2,trans-4-dienoyl-CoA at 2.1 and 1.75 Å resolution, respectively. The enzyme, a homotetramer, is a short-chain dehydrogenase/reductase with a distinctive ...