The Role of Fc Receptors on the Effectiveness of Therapeutic …
ADCC and ADCP are two mechanisms mediated by direct interaction of the antibody’s Fc domain with the corresponding FcγR. ADCC is mainly attributed to NK cells, but also neutrophils and …
FcγR Binding and ADCC Activity of Human IgG Allotypes
2020年5月6日 · Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated …
Antibody-dependent cellular cytotoxicity - Wikipedia
Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector …
Fc glycans of therapeutic antibodies as critical quality attributes
Therapeutic monoclonal antibodies recognizing cell surface expressed antigens, can engage Fcγ receptors (FcγR) on effector cells (monocytes, macrophages, natural killer (NK) cells, …
Systematic analysis of Fc mutations designed to reduce binding to Fc …
Binding to various Fc receptors on leucocytes induces antibody-dependent cell-mediated cytotoxicity (ADCC) or antibody-dependent cell-mediated phagocytosis (ADCP). Binding to the …
Effect of the ADCC-Modulating Mutations and the ... - ScienceDirect
2022年9月1日 · Six different Fc variants (Table 1) including ADCC + mutants (S239D, I332E, and S239D/I332E), the ADCC − mutant (L234A/L235A), IgG1 WT (control), and the IgG4Pro …
Boosting ADCC and CDC activity by Fc engineering and evaluation …
2014年1月1日 · Animal models and clinical data suggested important roles of Fc-mediated effector mechanisms such as antibody dependent cell-mediated cytotoxicity (ADCC) or …
Nature：Fc改造增强抗体药物ADCC活性和半衰期的研究简述@Med…
2022年12月3日 · ADCC是抗体药杀伤肿瘤细胞或病原微生物的重要机制之一，已知NK细胞、巨噬细胞、中性粒细胞等参与ADCC作用。 部分研究表明Fc尾与FcγRIIIA的高亲和力有益于抗体药 …
Effect of the ADCC-Modulating Mutations and the Selection of
In this report, we systematically characterize the effects of the mutations and IgG4 isotype on conformation stability, colloidal stability, solubility, and storage stability at accelerated …
Generation of new peptide-Fc fusion proteins that mediate …
Our results show that the Fc domain of human IgG1 when fused to cancer cell-binding peptides can enhance NK cell activation. Like conventional mAbs, the peptide-Fc fusion proteins …