In this paper, the author describes the creation of a visualization tool with drill-down capabilities for detailed study of the rare cases of special interest to implement an innovative method that …

eDISH (evaluation of Drug-Induced Serious Hepatotoxicity) is a well described method/tool that visually represent liver laboratory data of ALT/AST and Total Bilirubin in form of graph by …

Hepatocellular DILI Screening Plots Purpose: • Quickly identify cases of potential serious hepatocellular DILI that has led to sufficient liver damage (approaching 50% of total liver …

2025年2月11日 · As a two-dimensional graph that plots peak total bilirubin (TB) versus peak serum aminotransferase levels for each patient during study drug or comparator treatment, …

2023年5月1日 · Drug-induced liver injury (DILI), both intrinsic and idiosyncratic, causes frequent morbidity, mortality, clinical trial failures and post-approval withdrawal. This suggests an unmet …

2025年1月9日 · Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity. This study presents …

2024年1月10日 · DILI is a comprehensive repository aimed at enhancing the early detection of Drug-Induced Liver Injury (DILI) through the integration of predicted in vivo and in vitro data. …

Background & aims: Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a …

eDISH plot is a simple but very informative tool for medical reviewers that enables them to view individual lab patient data, study data or pooled data over time. eDISH plot allows the project …

2024年3月5日 · Ternary plot employed to characterize the distinct DILI phenotypes, including cholestatic, hepatocellular, mixed, and those observed in recovered patients.