DIO-B6小鼠是在C57BL/6背景品系上通过60%高脂饮食诱导的肥胖小鼠模型（DIO）。 该小鼠表现出体重增加、随机血糖升高、NK细胞和巨噬细胞增多以及部分血脂和肝功能指标升高的表型，可用于研究肥胖、糖尿病、炎症、脂肪肝等代谢类疾病，以及相关治疗药物的筛选 ...

Phenotype Information for JAX® Mice Strain B6 DIO (380050). DIO C57BL/6J mice do not develop overt type 2 diabetes, but they model early stages of the disease with phenotypes.

DIO C57BL/6J mice are a model of pre-diabetic type 2 diabetes and obesity with mildly elevated blood glucose and impaired glucose tolerance for your metabolic studies. Study ready diet-induced obese (DIO) C57BL/6J males and controls are placed on diet at 6 weeks of age, and are available from 7-25 weeks of age to suit your unique research needs.

百奥赛图开发了一系列肥胖和糖尿病模型，包括高脂饮食诱导肥胖 (DIO)小鼠模型，自发性糖尿病模型 (B-ob/ob小鼠)，STZ诱导糖尿病模型，同时可提供此类模型的药理药效服务。

因此一般单纯是高热量摄入引起的肥胖，称为饮食诱导的肥胖模型（DIO, Diet induced obesity）。 推荐使用 C57BL/6J 雄性小鼠。 有实验数据表明，雌鼠肥胖造模效果慢，成模难。 一般8-12周，12周最佳。 通常情况：6周龄（20g左右）C57BL/6J小鼠开始造模，饲喂高脂饲料至13-14周龄，体重可达35g；饲喂至16周龄体重可达40g左右；饲喂至20周龄体重可达46g-48g左右。 小鼠 推荐使用 60%脂肪供能高脂饮食（脂肪含量35%）。 大鼠 推荐使用 45%脂肪供能高脂饮食（脂 …

品系描述： DIO 小鼠 (DIO，Diet-Induced Obesity)是一种用于研究肥胖和糖尿病的动物模型，通过选择性繁殖具有肥胖和糖尿病易感性的小鼠，使其在高脂饮食条件下发展为肥胖和糖尿病。

2020年8月20日 · C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift...

通过长期喂饲高脂肪饲料，引起小鼠肥胖、空腹血糖上升并伴有体内脂肪堆积及胰岛素抵抗等表型。 南模生物对外提供DIO肥胖小鼠模型，并可提供基于此类模型的药效评价服务。 案例1： 小鼠品系：C57BL/6 性别：雄性 高脂饲喂起始周龄：5-6周

DIO mice in transit for an extended period of time (more than 48 hours) can lose 20-25% of their body weight and reach a new weight set point, making them resistant to high fat diet when they arrive.

Blood biochemical analysis in B-DIO mice. Male B-DIO mice were fed a high-fat diet for 12 weeks. Plasma concentrations of TG, TC, LDL-C, and HDL-C in B-DIO mice (HFD) and wild-type C57BL/6 mice with chow (control) were analyzed. The TC, HDL-C, LDL-C of B-DIO mice is significantly higher than that of control.