2024年12月24日 · DLX2 (Distal-Less Homeobox 2) is a Protein Coding gene. Diseases associated with DLX2 include Split-Hand/Foot Malformation 5 and Syngnathia. Among its related pathways are Sudden infant death syndrome (SIDS) …

Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene. [5] [6] Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes.

Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma.

2025年2月8日 · Dlx2 acts potently neurogenic in adult lateral subependymal zone cells in vitro. GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing lens: correlation with Dlx2 and Dlx5. DLX2 binds to a specific region of the TrkB promoter in retinal neuroepithelium during embryogenesis.

Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells. Title: Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.

Distal-less (Dlx) 基因家族包含至少 6 个不同的成员，DLX1-DLX6。 DLX 蛋白被假定在前脑和颅面发育中发挥作用。 该基因与 2 号染色体长臂上的基因家族的另一个成员呈尾对尾配置。 [RefSeq 提供，2008 年 7 月] Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes.

2021年6月15日 · DLX2 diminishes cellular senescence by regulating p53 function, whereas DLX4 has been associated with metastasis in breast cancer. In human ovarian cancer cells, DLX5 is essential for regulating AKT signaling, thereby promoting cell proliferation and survival.

2011年9月6日 · Dlx2 counteracts TGFβ-induced cell-cycle arrest and apoptosis in mammary epithelial cells by at least two molecular mechanisms: Dlx2 acts as a direct transcriptional repressor of TGFβ receptor II (TGFβRII) gene expression and reduces canonical, Smad-dependent TGFβ signalling and expression of the cell-cycle inhibitor p21(CIP1) and increases ...

2019年3月18日 · Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation, and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound...

DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2. Dlx and other homeobox genes in the morphological development of the dentition. [Genetic control of brain formation].