Homeobox protein DLX-5 is a protein that in humans is encoded by the distal-less homeobox 5 gene, or DLX5 gene. [5][6] DLX5 is a member of the DLX gene family. This gene encodes a member of a homeobox transcription factor gene family similar to …

2024年12月24日 · DLX5 (Distal-Less Homeobox 5) is a Protein Coding gene. Diseases associated with DLX5 include Split-Hand/Foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive and Split-Hand/Foot Malformation 1. Among its related pathways are Gene expression (Transcription) and Autodegradation of the E3 ubiquitin ligase COP1.

The homeodomain protein Dlx5 is an activator of Runx2 (a key regulator of osteogenesis) and is thought to be an important regulator of bone formation. At present, however, the perinatal lethality of Dlx5-null mice has hampered the elucidation of its ...

The human DLX homeobox genes, which are related to Dll (Drosophila distal-less gene), encode transcription factors that are expressed primarily in embryonic development. Recently, DLX5 was reported to act as an oncogene in lymphomas and lung ...

Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC). Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5. Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells.

In human ovarian cancer cells, DLX5 is essential for regulating AKT signaling, thereby promoting cell proliferation and survival. We previously implicated Dlx5 as an oncogene in murine T-cell lymphoma driven by a constitutively active form of Akt2.

2025年2月8日 · Title: Dlx5 promotes cancer progression through regulation of CCND1 in oral squamous cell carcinoma (OSCC). Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent DLX5.

Homeobox protein DLX-5is a protein in humans that is encoded by DLX5 gene. Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation.

DLX5 and DLX6 sit tail-to-tail in the genome and are expressed in SSCs, perichondrium cells, PHCs/HCs, and OBs.

The homeodomain protein Dlx5 is an activator of Runx2 (a key regulator of osteogenesis) and is thought to be an important regulator of bone formation. At present, however, the perinatal lethality of Dlx5-null mice has hampered the elucidation of its …