2021年1月1日 · DNA nanoflower has been demonstrated as a promising DNA nanostructure for therapeutics and bioimaging primarily because of the programmable DNA sequence and unique structure. Herein, we report manganese ions mediated enzymatic biomineralization to prepare DNA-Mn hybrid nanoflower (DMNF).

2020年4月12日 · The novel di-functional magnetic nanoflowers (DMNF) which had both epoxy groups and hydrophilic catechol as well as phthaloquinone groups capable of covalently coupling of penicillin G acylase (PGA) were characterized by scanning electron microscopy, transmission electron microscope (TEM), vibrating sample magnetometer, N 2 adsorption, and so on.

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2020年4月12日 · 研究表明，DMNF具有纳米片的“分层花瓣”结构，比饱和磁化强度为39.7 emu / g，平均孔径为25.4 nm，比表面积为17.28 m 2 /G。固定在DMNF上的PGA催化酶负载106 mg / g的青霉素G钾的水解，其表观活性达到2,667 U / g，这得益于磁性DMNF的“分层花瓣”和大孔结构。

2020年12月8日 · 在此，天津大学仰大勇等人报道了利用锰离子介导的酶促生物矿化作用制备DNA-Mn杂化纳米花（DMNF）。 本文要点： 1）探讨了顺磁性Mn2+作为DNA聚合酶的辅因子对长链DNA的扩增作用。 以长链DNA为模板 ，通过Mn2PPi的成核和生长，实现了DMNF的仿生合成。 通过调节反应时间和Mn2+浓度，可以控制DMNF的形貌和大小。 2）适配体序列被编码到环状模板中，实现DMNF的肿瘤靶向性，细胞摄取实验显示了适配体介导的细胞内吞作用。 3）DMNF在 …

2020年4月1日 · The novel di‐functional magnetic nanoflower (DMNF) containing epoxy groups, hydrophilic catechol, and pathaloquinone groups possessed the “hierarchical petal” and mesoporous structure, which ...

在此，天津大学仰大勇等人报道了利用锰离子介导的酶促生物矿化作用制备DNA-Mn杂化纳米花（DMNF）。 本文要点： 1）探讨了顺磁性Mn2+作为DNA聚合酶的辅因子对长链DNA的扩增作用。 以长链DNA为模板 ，通过Mn2PPi的成核和生长，实现了DMNF的仿生合成。 通过调节反应时间和Mn2+浓度，可以控制DMNF的形貌和大小。 2）适配体序列被编码到环状模板中，实现DMNF的肿瘤靶向性，细胞摄取实验显示了适配体介导的细胞内吞作用。 3）DMNF在酸性环境下表现 …

2020年8月30日 · The photothermal performance of DMNFPPL was revealed in Fig. 2 A–C, DMNFPPL could produce heat via an 808 nm laser irradiation, exhibiting power density- and concentration-dependent performances. At 12.5 μg/ml and irradiated by an 808 nm laser (3 W/cm 2) for 5 min, DMNFPPL solution could reach up 45 °C. All MNF-based formulations manifested ...

DMNF showed enhanced T 1-weighted magnetic resonance (MR) imaging effect in acid environment for high tumor-specific MR imaging, and high spatial resolution imaging of kidneys and liver. Our work provides a facile enzymatically biomineral strategy to integrate multifunctional modules into one DNA structure and promotes the development of DNA ...

DNA nanoflower has been demonstrated as a promising DNA nanostructure for therapeutics and bioimaging primarily because of the programmable DNA sequence and unique structure. Herein, we report manganese ions mediated enzymatic biomineralization to prepare DNA-Mn hybrid nanoflower (DMNF).