TETs compete with DNMT3 activity in pluripotent cells at ... - Nature
2020年6月8日 · Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed …
TET-mediated DNA demethylation controls gastrulation by
2016年10月19日 · These observations demonstrate that Tet and Dnmt act antagonistically to regulate DNA methylation at the Lefty genes, ensuring their proper expression to restrict Nodal …
TET repression and increased DNMT activity synergistically induce ...
2020年10月1日 · The results showed that a vicious combination of TET repression, due to NF-κB activation, and DNMT activation, due to NO production, is responsible for aberrant methylation …
The Role of DNMT Methyltransferases and TET Dioxygenases in …
2024年9月4日 · By combining the up-to-date information on the dysfunction of various enzymes that control the DNA "methylome" in the human body, we hope not only to draw attention to …
Base editing-mediated one-step inactivation of the Dnmt gene …
2023年5月22日 · Here, we establish a system of simultaneous inactivation of multiple endogenous genes in zygotes through screening for base editors that can efficiently introduce …
Competitive binding of TET1 and DNMT3A/B cooperates the DNA …
2022年10月1日 · Here, we revealed that the main DNA-binding domain of TET1 contains more positive charges by using charge reduction of amino acid alphabet, followed by DNMT3A and …
Regulation of CpG methylation by Dnmt and Tet in pluripotent …
It has been reported that DNA methyltranseferases (Dnmts) function as methylation writers and maintainers, and ten-eleven translocation (Tet) acts as a methylation eraser (Fig. 1). …
<br>DNMT 甲基转移酶和 TET 双加氧酶在维持 DNA 甲基化水平 …
在人体细胞中执行此类过程的酶组仅限于两个家族的代表，即 DNMT（DNA 甲基转移酶）和 TET（DNA 双加氧酶）。 该综述提供了当今已知的有关这些家族中每个功能重要成员的详细信 …
DNMT3A and TET1 cooperate to regulate promoter epigenetic …
2018年7月12日 · Here we demonstrate that DNMT3A and TET1 function in a complementary and competitive manner in mouse embryonic stem cells to mediate proper epigenetic landscapes …
TET repression and increased DNMT activity synergistically induce ...
In biological settings, chronic inflammation can induce both TET repression and increased DNMT activity. This vicious combination was considered to cooperatively induce aberrant DNA …