DNA methyltransferase - Wikipedia
DNMT3 is a family of DNA methyltransferases that could methylate hemimethylated and unmethylated CpG at the same rate. The architecture of DNMT3 enzymes is similar to that of …
不同DNA甲基转移酶DNMT）在癌症发病机制中的作用
2023年2月7日 · DNA甲基化是指以共价结合方式获得一个甲基（CH3）基团的过程，其是在DNA序列特定碱基的DNMT催化下作为CH3供体的S-腺苷甲硫氨酸（SAM）的化学修饰过程。 在此 …
Comprehensive structure-function characterization of DNMT3B …
2020年7月3日 · Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism …
靶向DNA甲基转移酶DNMT的肿瘤治疗 - 知乎 - 知乎专栏
研究显示，DNMT2的功能主要是催化RNA的甲基化，而DNMT3L并不具备催化活性，所以我们在谈论DNMT的时候，一般指的是DNMT1和DNMT3a/3b。 虽然DNMT1和DNMT3a/3b这两个蛋 …
The DNA methyltransferase family: a versatile toolkit for ... - Nature
2017年10月16日 · DNMT1, DNMT3A and DNMT3B are canonical cytosine-5 DNMTs that catalyse the addition of methylation marks to genomic DNA. By contrast, DNMT2 and DNMT3L are non …
The de novo DNA methyltransferase DNMT3A in development …
2022年3月4日 · DNA methylation, one of the best-characterized epigenetic modifications, plays essential roles in development, aging and diseases. The de novo DNA methyltransferase …
Structural basis for DNMT3A-mediated de novo DNA methylation
2018年2月7日 · Here we report a 2.65-ångström crystal structure of the DNMT3A–DNMT3L–DNA complex in which two DNMT3A monomers simultaneously attack two …
The DNMT3 family of mammalian de novo DNA methyltransferases
This review focuses on recent developments in the characterization of the DNMT3 family of DNA methyltransferases at the biochemical, structural, and functional levels. Interconnections …
蓝斐团队报道H3K36me2 调控DNMT3A建立DNA甲基化的机制
近日，我院蓝斐研究员、吴飞珍副研究员和沈宏杰青年研究员合作在Protein & Cell 在线发表题为“DNMT3A Reads and Connects H3K36me2 to DNA Methylation”的短文，报道了DNMT3A可以 …
DNA 甲基转移酶 | DNA methyltransferases (DNMTs) | MCE
Five DNMT enzymes have been identified in mammals including DNMT1, DNMT2, DNMT3A, DNMT3B, and DNMT3L. DNMTs can be used for the research of epigenetic mechanisms. …
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