Methods and results: Forty-one DNTs classified as three histological forms were investigated with CD34 and microtubule-associated protein 2 (MAP2) immunohistochemistry. CD34 …

2024年6月12日 · Allogeneic double-negative T cells (DNTs) are a rare T-cell subset that effectively target acute myeloid leukemia (AML) without inducing graft-versus-host disease in …

2011年5月13日 · These data demonstrate that ex vivo expanded DNT cells from AML patients can kill primary CD34 + leukemic blasts in vitro and that both DNT cell subsets contribute to …

2018年4月24日 · We also observe complementary activity between conventional chemotherapy and DNT therapy on CD34 + primary AML samples, which suggests that DNTs can target …

In this study, we explored a non-conventional T cell subset named double negative T cells (DNTs) as a novel therapy to target AML, including leukemic cells that are resistant to the conventional …

2021年4月22日 · Dead cells were identified as the CD3 − /Annexin V + population. For patient leukemic blasts, cells were stained with CD45, CD33, CD34, CD3, and CD64 to identify …

DNT include the specific form and the controversial non-specific form that lack the specific glioneuronal element. Our aims were to search for BRAF(V600E) mutation and CD34 …

2023年4月28日 · 双阴性T细胞（DNT）是外周成熟T细胞，表达CD3，但不表达CD4、CD8或自然杀伤（NK）T细胞标志物。 尽管这些细胞代表了外周血中约1-5%的T淋巴细胞的一个小亚 …

2021年7月22日 · DNTs were cocultured with target cells for 2 to 4 hours, and cells were then stained with anti-human CD3 (HIT3a), CD33 (WM53), CD45 (HI30), and CD34 (561) …

Immunoreactivity for CD34 and nestin characterizes the dDNT and helps to distinguish it from other lesions associated with epilepsy. Histological evidence indicative of transition of dDNT to …