Dec 2, 1992 · We describe here the isolation and characterization of a cell line, DOK (dysplastic oral keratinocyte), from a piece of dorsal tongue showing epithelial dysplasia. The tissue was obtained from a 57-year-old man who was a heavy smoker prior to the appearance of a white patch on his tongue.

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype. The p53 status of cultured human premalignant oral keratinocytes. Signatures of mutation and selection in the cancer genome.

Oct 11, 2011 · Current organotypic models of dysplasia and oral squamous cell carcinoma (OSCC) lack the complexity that mimics in vivo tissue. Here we describe a three-dimensional in vitro model of the oral...

The dysplastic oral keratinocyte cell line DOK was isolated from a piece of dorsal tongue from a 57 year old man. After a squamous-cell carcinoma was removed from the patient, who had been a heavy smoker, the remaining dysplasia was removed subsequently and used to initiate primary cultures leading to the establishment of DOK.

Sep 5, 2023 · DOK cells are noninvasive cells, but overexpression of STIM1 and ORAI1 increased the ability of DOK cells to migrate through the extracellular matrix (ECM) in vitro (Fig. 2, D and E, and fig. S9B). These data support the notion that SOCE is involved in the transformation of oral dysplasia to cancer by enhancing the expression of key biomarkers ...

leukoplakia cell line DOK. Cell morphology, proliferation ability, migration ability, colony formation, and tumorigenicity were studied and confirmed the malignant characteristics of...

Jul 26, 2019 · DOK cell line is a dysplasitc oral keratinocyte derived from a heavy smoker with OSCC. The differentially expressed genes between DOK and normal human oral keratinocytes (HOK) may provide important information about OSCC carcinogenesis mediated by …

DOK cells are non-tumourigenic in athymic nude mice. This cell line can be used to study carcinogens associated with tobacco and their implications in malignant transformation. Application: Study of oral keratinocytes, multi-stage oral carcinogenesis

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype. The degree of dysplasia in the patient was described as mild to moderate. The cells show some stratification in confluent.

Jan 5, 2022 · Cell information for DOK. Find diseases associated with this biological target and compounds tested against it in bioassay experiments.