2024年5月13日 · There is a large number of PET radiotracers to assess various elements of dopaminergic system such as F-18 fluorodopamine to assess dopamine transfer and storage in peripheral catecholamine-synthesizing cells, F-18 FDOPA to assess L-DOPA transfer via l-amino acid transporters, conversion of L-DOPA to dopamine by aromatic l-amino acid ...

To investigate presynaptic function, PET-tracers have been developed to measure dopamine synthesis and transport. For the former the most commonly used tracers are 6-[(18)F]FDOPA and 6-[(18)F]FMT, whereas for the latter several (11)C/(18)F …

Here, we review select PET papers reporting the effects of smoking or behavioral tasks on DA transmission. The papers help to illustrate the need for sophisticated modeling to properly detect and quantify the contribution of the DA signal to the PET data.

2023年9月30日 · We use positron emission tomography (PET) imaging to directly measure dopamine synthesis capacity and D 1 and D 2/3 receptor availability in 57 healthy adults who complete a computerized...

2019年1月1日 · Over the past three decades, PET imaging of dopamine D2/D3 receptors using [11 C]raclopride, [18 C]fallypride, and [11 C]-(+)-PHNO has provided important insights into normal neurobiology as well as pathophysiology of neurological disease including addiction, Parkinson’s disease, ADHD, and schizophrenia. We have proposed a method for ...

2025年3月28日 · Scientists have confirmed a neurobiochemical link between dopamine and cognitive flexibility. PET imaging shows that the brain increases dopamine production when completing cognitively demanding ...

2 天之前 · A scout CT scan was acquired, and the bed was positioned for a 90 min PET scan centred on the head. 50 MBq of [18 F]Flurodopa (70-800 μL injection volume) was administered via tail vein immediately before PET scan start. A 2.5 min CT scan was acquired (50KeV, 480 projections) at scan end for anatomical reference and attenuation correction.

Several antagonist PET radioligands for the dopamine D 1 receptor have been developed successfully. In addition, well-validated antagonist PET and SPECT radioligands are available for imaging of dopamine D 2 and dopamine D 3 (D 2/3) receptors in the living human brain.

PET imaging of dopaminergic system and clinical applications The aim of this review is to overview the dopamine, PET radiotracers of dopaminergic system and their clinical applications. This includes dopamine synthesis, dopamine receptors, role of dopamine in physiological functions and diseases, PET radiotracers of dopaminergic system and ...

2025年3月28日 · PET imaging analysis showed a displacement of 18 F-fallypride in the ventromedial prefrontal cortex during the task switching (higher cognitive demand) part of the study, which is assumed to be the release of dopamine. Results also showed that the greater dopamine release, the more efficient participants were in switching between tasks.