Stimuli-responsive polymer-doxorubicin conjugate: Antitumor …
2019年1月15日 · The therapeutic indexes therefore are significantly improved by the diblock pDHPMA-DOX polymeric nanoprodrug against 4T1 tumors, inhibiting 54% of the tumor growth …
Synergistic effect of tumor chemo-immunotherapy induced by ... - Nature
2021年8月6日 · Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further …
Co-delivery of IOX1 and doxorubicin for antibody-independent …
2021年4月23日 · IOX1 effectively downregulates tumour PD-L1 expression in vitro and in vivo. Simultaneously, it inhibits cancer cell’s multidrug resistance and promotes intracellular DOX …
Targeting miR-21 to Overcome P-glycoprotein Drug Efflux in …
2024年10月21日 · In this study, we demonstrate that miR-21 affects chemoresistance in 4T1 TNBC cells in response to doxorubicin (DOX) by regulating the P-glycoprotein (P-gp) drug …
Efficacy of PolyMPC–DOX Prodrugs in 4T1 Tumor-Bearing Mice
2014年4月21日 · The aggressive 4T1 mouse model reveals the potential for polyMPC–DOX in the treatment of triple negative breast cancer, and ongoing studies include evaluating the in vivo …
Neoadjuvant chemotherapy by liposomal doxorubicin boosts …
2025年1月21日 · NP-Dox chemotherapy increased their expression in 4T1 and B16-F10 tumors (Figures S2 G and S2H). We also evaluated PD-L1 expression as increased MHC class I …
Doxorubicin resistant cancer cells activate myeloid-derived suppressor ...
2016年4月1日 · Here we demonstrated, for the first time, that PGE 2 secreted by doxorubicin-resistant breast cancer 4T1 cells enhanced the expansion and M2 polarization of MDSCs via …
<br>靶向 miR-21 以克服阿霉素耐药 4T1 乳腺癌中的 P-糖蛋白药 …
In this study, we demonstrate that miR-21 affects chemoresistance in 4T1 TNBC cells in response to doxorubicin (DOX) by regulating the P-glycoprotein (P-gp) drug efflux pump. …
浙大周民团队Adv. Funct. Mater.封面文章：通过光激活的组装纳米 …
2018年7月17日 · (A) DOX、TSNCs和TSNCs+laser 在4T1 原位肿瘤组织内血管附近和血管稀少区域的分布。 激光共聚焦显微镜扫描各组处理后肿瘤组织切片的蓝色荧光（细胞核）、红色荧 …
Prevention of metastasis in a 4T1 murine breast cancer model by ...
2011年5月30日 · For example, a doxorubicin (DOX) loaded immunoliposome targeting MUC1 on 4T1-MUC1 tumor in mice showed some efficacy in early lesions but not in advanced lesions …