To examine whether PPARβ represses the activity by modulating binding of LXRα to the DR4 element, the LXRα ORF was fused to the yeast transcription factor GAL4 to produce a DR4- …

2019年6月7日 · Current models propose that DR spacer length is a key determinant of DNA-binding specificity for NRs 2, 8, 10, 11, 12. For example, PPAR:RXR dimers prefer binding to …

Current models propose that DR spacer length is a key determinant of DNA-binding specificity for NRs 2, 8, 10 – 12. For example, PPAR:RXR dimers prefer binding to DR1 elements, whereas …

activated receptors (PPAR). Within the ME promoter, two direct repeat (DR)-1-like elements, MEp and MEd, have been identified as putative PPAR response ele-ments (PPRE). We …

Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors …

1997年8月8日 · We demonstrate that, in contrast to the polarity of RXR/TR and RXR/RAR bound to DR4 and DR5 elements respectively, PPAR binds to the 5′ extended half-site of the …

2012年1月31日 · De novo analysis of LXR binding sequences identified a DR4-type element as the major motif. On mRNA level T09 up-regulated 1258 genes and repressed 455 genes. Our …

2013年12月31日 · We performed in vitro dose responses to determine the concentration of dsDNA consensus RE (DR1 or DR4) required to induce a maximal BRET response for …

In this study, it was shown that the complexes of the retinoid X receptor (RXR) with either the vitamin D3 receptor (VDR), the thyroid hormone receptor (T3R) or the liver X receptor (LXR) …

1997年8月8日 · Within the ME promoter, two direct repeat (DR)-1-like elements, MEp and MEd, have been identified as putative PPAR response elements (PPRE). We demonstrate that only …