2025年2月15日 · First, cell-lethal pharmacologic ISR-inducers upregulated DR5 mRNA and protein (Fig. 1A, B) and actuated apoptosis downstream of DR5 (Fig. 1B), as did the stress-free activation of the ISR...

2003年10月29日 · Here we show that agonists of DR5 can act as pharmacological agents that are synthetically lethal with MYC overexpression, potently inducing apoptosis in human cells overexpressing the MYC oncogene, both in vitro and in tumor xenografts in vivo.

2025年1月15日 · Death receptor 5 (DR5) mediates extrinsic apoptosis. We engineer DR5 agonistic single-chain variable fragment (scFv) expression on the surface of sEVs derived from natural killer cells. PDGFR transmembrane domain delivers DR5-scFvs to the surface of sEVs.

2017年4月14日 · However, a recent report suggested a central role for the death receptor, DR5, activated in a ligand-independent manner, and the initiator caspase, caspase-8, in ER stress-induced cell death....

Here we show that agonists of the TRAIL death receptor DR5 potently induce apoptosis in human cells overexpressing the MYC oncogene, both in vitro and as tumor xenografts in vivo. MYC sensitizes cells to DR5 in a p53-independent manner by upregulating DR5 cell surface levels and stimulating autocatalytic processing of procaspase-8.

2005年10月6日 · We showed that MYC activation results in up-regulation of cell surface levels of death receptor 5 (DR5; also known as TRAIL-R2, TNFRSF10B), an apoptosis-inducing receptor for the cytokine TNF-related apoptosis-inducing ligand (TRAIL) (reviewed in refs. 6 and 7).

a new model of self-associated DR5 ECDs lying horizontal to the membrane prior to ligand engagement, termed pre-ligand self-association. The mechanisms of death receptor (DR) signaling have been

总体而言，研究结果表明，dr5/trail 介导的细胞凋亡通路在 ars 小鼠的损伤中发挥了重要作用，dr5 可能是 ars 治疗的潜在靶点。 而 DR5 凋亡拮抗剂 sDR5 融合蛋白可能是一种有前途的抗 ARS 候选药物，值得进一步研究。

Here we show that agonists of the TRAIL death receptor DR5 potently induce apoptosis in human cells overexpressing the MYC oncogene, both in vitro and as tumor xenografts in vivo. MYC sensitizes cells to DR5 in a p53-independent manner by upregulating DR5 cell surface levels and stimulating autocatalytic processing of procaspase-8.

The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but …