2024年12月25日 · HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Celiac Disease and Graham Little-Piccardi-Lassueur Syndrome. Among its related pathways are TCR Signaling (Qiagen) and Phosphorylation of CD3 and TCR zeta chains.

The polypeptide subunit encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II protein is a heterodimer consisting of an alpha (DRα) and a beta chain (DRβ), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

2024年11月5日 · hla-dra(人类白细胞抗原-dr alpha)是人类白细胞抗原系统（hla系统）中mhc ii类分子的重要组成部分，广泛表达于抗原呈递细胞(如树突状细胞、单核细胞和b细胞)中。

2024年12月10日 · Human Leukocyte Antigen DR (HLA-DR), Major Histocompatibility Complex class II molecules (MHC-II) induce a relocation of Gag to late endosomal/multivesicular bodies (LE/MVB) and increase the accumulation of viral particles assembling intracellularly

hla-dra 是 hla ii 类α链旁系同源物之一。 这种 II 类分子是由 α 和 β 链组成的异二聚体，它们都锚定在膜中。 该分子在 B 淋巴细胞、树突状细胞和单核细胞/巨噬细胞等各种抗原呈递细胞的表面表达，并通过呈递细胞外蛋白肽，特别是病原体衍生肽，在免疫系统和 ...

HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC. Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.

2024年10月28日 · Clinical resource with information about HLA-DRA, A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations., A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3 ...

The purpose of this review is to provide an interpretative view of work from our laboratory on the DRA gene, and incorporate it with work from other laboratories. Specially, we will deal with: (a) the functional roles of transcription factors in DRA gene regulation; (b) the mechanisms of …

2016年9月14日 · Gene target information for HLA-DRA - major histocompatibility complex, class II, DR alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

This article reviews our current understanding of transcriptional regulation of one such human class II MHC gene, DRA. Considerable effort has been exerted toward characterizing the cis-acting regulatory sequences and trans-acting DNA binding proteins responsible for regulating DRA transcription.