2021年5月8日 · Dre（D6 site-specific DNA recombinase）也是从噬菌体中发现的一种酪氨酸重组酶，其识别的是 32bp 的 DNA 序列 rox，包含两个 14bp 反向回文序列和 4bp 的中间间隔序列。Dre 重组酶和 Cre 重组酶具有特异性，Dre 重组酶不能识别 loxp 位点，同时 Cre 重组酶也不能识 …

Tyrosine site-specific recombinases (SSRs) including Cre and FLP are essential tools for DNA and genome engineering. Cre has long been recognized as the best SSR for genome engineering, particularly in mice. Obtaining another SSR that is as good as Cre will be a valuable addition to the genomic tool …

GemPharmatech offers a diverse range of Cre/Dre mice, totaling more than 200 Cre strains and 9 Dre/DreER strains. These strains have been thoughtfully designed to ensure efficient and reliable Cre-mediated recombination in vivo. Additionally, we provide over 50 inducible CreER strains for inducible Cre recombination in your research.

该工具鼠表达由广泛型CAG启动子驱动的Dre重组酶。 Dre-rox与Cre-loxP系统相似，Dre重组酶识别rox位点可介导染色体重组。 应用领域 ：广泛表达Dre工具鼠

2021年6月3日 · We generated Ucp1-Dre mice (Figure 4 E) and crossed them with R26-rox-tdTomato reporter mice, finding strong tdT + signals in BAT and weak tdT + signals in ingWAT or epiWAT (Figure 4 F). Immunostaining for tdTomato and PLIN1 confirmed that Ucp1-Dre mainly targeted BAs in the BAT and minimally targeted WAs in the WAT ( Figures 4 G and 4H).

2023年6月9日 · To overcome these limitations, we developed and characterized a dual recombinase transgenic mouse, which combines the Cre and Dre recombinase systems. This mouse allows for tamoxifen-inducible Cre-dependent expression of exogenous genes or knockout of floxed genes in ZnT3-expressing neurons and DreO-dependent region and cell type–specific ...

2018年9月27日 · The multi-reporter mouse line for loci-of-recombination (X) (MuX) will be useful to characterize recombination characteristics of mice expressing either Cre, Flp, Dre or Vika recombinase and...

2017年11月13日 · In the Tnni3–Dre × Kit–Cre ER × IR1 mice, Dre first removes one loxP site and ZsGreen from the interleaved reporter allele in cardiomyocytes, precluding potential Cre–loxP-mediated ...

To enable more specific cell lineage tracing and ablation through dual recombinase activity, we generated two mouse lines that render Dre- or Dre+Cre-mediated recombination to excise a stop codon sequence that prevents the expression of diphtheria toxin receptor (DTR) knocked into the ubiquitously expressed and safe Rosa26 locus.

本文旨在构建光激活的Dre重组酶（photoactivatable Dre，PA-Dre）系统及Cre激活的光诱导Dre（Cre-Activated Light Inducible Dre，CALID）系统并在小鼠体内和脑内特定的细胞群体中实现时空特异性的基因调控。