Copper cells in the Drosophila midgut were originally named for their ability to accumulate dietary copper. Recent studies have uncovered a number of intriguing similarities between copper cells and the acid-producing gastric parietal cells of the mammalian stomach.

Studies of the adult Drosophila midgut have led to many insights in our understanding of cell-type diversity, stem cell regeneration, tissue homeostasis, and cell fate decision. Advances in single-cell RNA sequencing provide opportunities to identify new cell types and molecular features.

2013年7月11日 · Dpp secreted from enterocytes at the boundary between the posterior midgut and the middle midgut (MM) sets up a morphogen gradient that selectively directs copper cell (CC) regeneration from gastric SCs in the MM and thus determines the size of the CC region.

2014年3月7日 · Quiescent, multipotent gastric stem cells (GSSCs) in the copper cell region of adult Drosophila midgut can produce all epithelial cell lineages found in the region, including...

The middle midgut (R3) contains a copper cell region in R3ab, which produces gastric acid, followed by a large flat cell region (R3c) with unclear function. Two boundaries flanking this region are inflection points where the midgut folds stereotypically inside the body cavity.

2007年2月8日 · In Drosophila, the metal‐responsive transcription factor (MTF‐1) plays a dual role in copper homeostasis: at limiting copper concentrations, it induces the Ctr1B copper importer gene, whereas at high copper concentrations, it mainly induces the metallothionein genes.

2016年11月15日 · Dad and Dpp activity is dynamically regulated in the adult Drosophila middle midgut. Dynamic regulation of Dad is required for gastric stem cell differentiation. Ubx is required to repress Dad for the regeneration of acid-producing copper cells. The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia.

2004年6月1日 · Copper cells in the Drosophila midgut were originally named for their ability to accumulate dietary copper. Recent studies have uncovered a number of intriguing similarities between...

2016年6月2日 · The acidic region of Drosophila midgut contains a unique subset of cells–the copper cells–with a highly invaginated apical membrane, similar to the mammalian gastric parietal cells 10,...

The adult Drosophila copper cell region or “stomach” is a highly acidic compartment of the midgut with pH < 3. In this region, a specialized group of acid-secreting cells similar to mammalian gastric parietal cells has been identified by a unique ultrastructure and …