浅析抗体偶联药物ADC（附常见Linker名称及结构式大全）
2022年4月28日 · 抗体偶联药物 （ Antibody-drug conjugates，ADC ）是一类融合了抗体与小分子细胞毒素两种组分的新兴药物。其中抗体提供细胞靶向性，可以将药物比较精准的输送到靶细 …
Drug-Linkers in Antibody–Drug Conjugates: Perspective on …
2023年6月29日 · ADCs are a hybrid construct combining, via chemical conjugation, biologic (monoclonal antibody) and small-molecule (drug-linker) moieties into a single drug substance. …
ADC的偶联技术 - 知乎 - 知乎专栏
Linker-drug (LD) 与抗体的偶联是产生ADC和确定ADC关键质量属性的关键步骤，其可以从根本上改变ADC的药代动力学和治疗指数。 目前超过95%的ADC基于两种偶联技术：半胱氨酸烷基 …
ADC：可裂解Linker的分类、案例、作用机制 - 搜狐
2023年7月27日 · 抗体药物偶联物 (ADC)作为新兴的抗癌治疗药物，可以将高细胞毒性分子直接递送至癌细胞发挥杀伤作用。 ADC是由单克隆抗体通过Linker与细胞毒性化学物质 (Payload)共 …
Antibody–drug conjugates: Recent advances in linker chemistry
2021年12月1日 · Antibody–drug conjugate (ADC), comprising a monoclonal antibody (mAb), the cytotoxic payload and the linker, has developed rapidly in recent years and is gradually …
PEG Linker：促进ADC药物靶向治疗的关键连接剂 - 知乎
抗体偶联药物（Antibody Drug Conjugates，ADC）是一类新型强效抗肿瘤药物，结合了抗体的靶向能力和细胞毒药物的杀伤效应，在肿瘤治疗领域展现出了优秀的疗效和潜力。
An Introduction to Linkers in Antibody-Drug Conjugates (ADCs)
2024年9月30日 · Antibody-drug conjugates (ADCs) are “biological bullets” that combine cytotoxic drugs (payloads) with antibodies through “linkers.” ADCs consist of five key elements: target, …
Recent Advances in Smart Linkage Strategies for Developing Drug ...
2 天之前 · In recent years, drug conjugates have emerged as a promising targeted delivery system [].They typically consist of a targeting carrier, a linker, and a payload and are designed …
A B7H3-targeting antibody–drug conjugate in advanced solid
2 天之前 · Antibody–drug conjugates (ADCs) have emerged as a transformative modality in the treatment of solid tumors. YL201, a novel B7H3-targeting ADC, leverages a tumor …
Preclinical evaluation of a novel antibody–drug conjugate ... - Nature
2 天之前 · OBI-992 is an investigational ADC composed of a novel TROP2 antibody (R4702) conjugated with exatecan through a hydrophilic enzyme-cleavable peptide linker (the structure …