2021年8月5日 · In this review article, we outline the current state of knowledge about DSF, its broad pharmacological action, as well as therapeutic effects, with a particular emphasis on the molecular understanding of its potential pharmacodynamic interactions with common addictive substances (e.g., alcohol, cocaine, cannabinoids, opioids) supported by releva...

2022年2月1日 · In this review, a critical summarization of various molecular biological anticancer mechanisms of DSF/Cu 2+ is provided and the predicament of orally delivering DSF in clinical oncotherapy is explained by the metabolic barriers.

2017年12月6日 · Among promising cancer-killing drugs 2 is disulfiram (tetraethylthiuram disulfide, DSF), a drug that has been used for over six decades as a treatment for alcohol dependence 3, with...

2023年6月16日 · Combination therapy with DSF/Cu 2+ and an anti-PD-1 antibody showed much better antitumor efficacy than monotherapy. In terms of cytokine/chemokines release, DSF could reduce expression of inflammatory cytokines and chemokines and reduced CD86 and MHC class II expressions during inflammation, autoimmune diseases, or tumors.

2021年1月10日 · The identification of DSF as a FROUNT inhibitor with synergistic antitumour effects when combined with immune checkpoint therapy suggested that the modulation of chemokine signalling by targeting FROUNT represents a promising and readily realizable strategy for macrophage-targeted cancer therapy.

In this review, we summarize the antitumor mechanisms of DSF/Cu, including induction of intracellular reactive oxygen species (ROS) and various cell death signaling pathways, and inhibition of proteasome activity, as well as inhibition of nuclear factor-kappa B (NF-κB) signaling.

2024年6月20日 · Disulfiram (DSF), a Food and Drug Administration (FDA)-approved drug used to treat chronic alcoholism, has a great potential as an anticancer drug by targeting diverse human malignancies.

Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer efficacy, and its supplementation with copper (CuII) significantly potentiates ...

2019年6月28日 · Both in vitro cellular assays and in vivo tumor-xenograft experiments demonstrated the efficient Cu-enhanced and tumor-specific chemotherapeutic efficacy of DSF, with cocontributions from highly toxic CuET complexes and ROS generated within tumors.

Disulfiram (DSF), primarily applied in the therapy for alcohol addiction, has been demonstrated to possess the promising capability of anti-tumor in many human cancers, including esophageal squamous cell carcinoma (ESCC). To date, almost all studies about DSF in ESCC are focusing on investigating ei …