The FDA is announcing its decision to approve Hameln's new drug applications (NDAs) for pentetate calcium trisodium injection (Ca-DTPA) and pentetate zinc trisodium injection (Zn-DTPA) for...

Pentetic acid or diethylenetriaminepentaacetic acid (DTPA) is an aminopolycarboxylic acid consisting of a diethylenetriamine backbone with five carboxymethyl groups. The molecule can be viewed as an expanded version of EDTA and is used similarly. It is a white solid with limited solubility in water.

2025年1月31日 · DTPA (Diethylenetriamine pentaacetate) is a medicine that helps reduce radioactive material in the body. DTPA helps the body remove radioactive contamination through urine. DTPA works best when given shortly after radioactive material has entered the body.

According to FDA labeling, the chelating agents Ca-DTPA (FDA drug label, PDF - 121 KB) and Zn-DTPA (FDA drug label, PDF - 106 KB), salts of diethylentriamene pentaacetate (DTPA), are approved for the elimination of known or suspected internal contamination with the transuranic (Z > 92) metals plutonium, americium, and curium.

zn-dtpa和ca-dtpa不能同时使用，fda推荐首选ca-dtpa，如需额外治疗，则转用zn-dtpa持续治疗。 如果是多种方式导致体内污染，则静脉滴注方式效果更好。 治疗持续的时间可根据体内污染程度和患者对治疗的反应来确定。

2022年1月12日 · Ca-DTPA (pentetate calcium trisodium) is a chelating agent used to treat patients with known or suspected internal contamination with plutonium, americium, or curium to increase the rates of elimination. What Are Side Effects of …

Diethylenetriaminepentaacetate (Zn-DTPA and Ca-DTPA) is a chelating agent that is used in exposures to the transuranic elements plutonium, americium, and curium. DTPA is used as a salt of calcium or zinc and forms a chelate that is excreted in the urine. DTPA has a plasma half-life of 20–60 minutes and is distributed in the extracellular space.

Pentetic acid, also known as diethylenetriaminepentaacetic acid (DTPA), is a synthetic polyamino carboxylic acid with eight coordinate bond forming sites that can sequester metal ions and form highly stable DTPA-metal ion complexes.

DTPA anhydride is a bifunctional chelator whose anhydride can react with amino groups in proteins (such as lysine residues) to form stable amide bonds. DTPA anhydride can also bind to radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs).

DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist. OVERDOSE: If someone has overdosed and has serious...