2025年1月31日 · DTPA (Diethylenetriamine pentaacetate) is a medicine that helps reduce radioactive material in the body. DTPA helps the body remove radioactive contamination through urine. DTPA works best when given shortly after radioactive material has entered the body.

Pentetic acid or diethylenetriaminepentaacetic acid (DTPA) is an aminopolycarboxylic acid consisting of a diethylenetriamine backbone with five carboxymethyl groups. The molecule can be viewed as an expanded version of EDTA and is used similarly. It is a white solid with limited solubility in water.

The FDA is announcing its decision to approve Hameln's new drug applications (NDAs) for pentetate calcium trisodium injection (Ca-DTPA) and pentetate zinc trisodium injection (Zn-DTPA) for the...

Ca-DTPA and Zn-DTPA can be administered by nebulizer or directly into the blood stream (i.e. intravenously). If the route of internal contamination is through inhalation alone, then nebulized chelation therapy will suffice.

Diethylenetriaminepentaacetate (Zn-DTPA and Ca-DTPA) is a chelating agent that is used in exposures to the transuranic elements plutonium, americium, and curium. DTPA is used as a salt of calcium or zinc and forms a chelate that is excreted in the urine. DTPA has a plasma half-life of 20–60 minutes and is distributed in the extracellular space.

Diethylenetriaminepentaacetate (Zn-DTPA and Ca-DTPA) is a chelating agent that is used in exposures to the transuranic elements plutonium, americium, and curium. DTPA is used as a salt of calcium or zinc and forms a chelate that is excreted in the urine. DTPA has a plasma half-life of 20–60 minutes and is distributed in the extracellular space.

DTPA is a chelating agent used for radioactive plutonium, americium, and curium. When bound to these radionuclides, DTPA accelerates renal elimination from the body in urine and effectively reduces the duration of radiation exposure the body receives.

DTPA于本世纪五十年代后期应用于放射性核素的促排,至今已有20多年的历史。 临床上所用的DTPA,一般为其三钠钙盐 (以下作Ca-DTPA),毒付作用较大。 为了克服这一缺点,于六十年代以后,人们对DTPA的三钠锌盐 (以下作Zn-DTPA)越来越重视,以至成为当前促排研究的重要动向之一¹。 迄今得到的动物实验结果是令人鼓舞的,而且国内外均已开始试用于人体。 可以说,Zn-DTPA过渡到临床应用的阶段已经到来。

2025年1月7日 · DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It is FDA approved for the treatment of individuals with known or suspected internal contamination with plutonium, americium or curium to increase the rates of elimination.

2023年2月27日 · Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR). excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.