DU145 (DU-145) is a human prostate cancer cell line. [1] DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research. [1]

DU 145 is a cell line with epithelial morphology that was isolated from the brain of a 69-year-old, White, male with prostate cancer. This cell line is suitable as a transfection host.

2006年4月17日 · The majority of human prostate cancer cell lines, including the two "classical" cell lines DU-145 and PC-3, are reported to be androgen receptor (AR)-negative. However, other studies have provided evidence that the DU-145 and PC-3 cell lines express AR mRNA.

DU-145 is an aggressive tumorigenic prostate cancer cell line with moderate metastatic potential. Used for developing the DU145 xenograft model in immunocompromised mice to study prostate cancer biology, development, and growth in vitro and in vivo.

A cell line made from human prostate cancer cells that is used in the laboratory to study the way prostate cancer cells grow.

PC3 and DU145 cell lines were more invasive than LNCaP cells, consistent with their known metastatic potentials. We found a strong correlation between the expression pattern of TLR4 and the invasive potential of prostate cancer cell lines used (Figs. 1 and 2).

DU-145. The DU145 cell line was established from the brain metastasis of a 69-year-old prostate cancer patient . These cells express CK5, CK7, CK8, CK18, and CK19 [93,144,145]. Being AR negative, DU145 cells are hormone-insensitive and do not express PSA .

The DU-145 xenograft model enables studies of tumor growth inhibition by systemic viral agents, small molecules (farnesol, darinaparsin, taxotere) or siRNA/miRNA. DU145 xenografts are mouse models of human prostate cancer that are created by …

Unfortunately, most of the PC cell lines are androgen independent (like DU145), or express mutated forms of androgen receptor (AR). We have produced and characterized a new stably transfected PC line expressing the AR (DU145-AR).

Xenograft models consist of subcutaneous injection of human cancer cells in immunocompromised mice. The DU145 cell line derived xenograft (CDX) is routinely utilized in preclinical experiments for determining efficacy of test compounds.