2019年10月1日 · BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and …

2013年1月24日 · We further identify the deubiquitinating enzyme, BRCC3, as a critical regulator of NLRP3 activity by promoting its deubiquitination and characterizing NLRP3 as a substrate …

2013年1月24日 · By screening a DUB library, we identify BRCC3 as a regulator of NLRP3 ubiquitination and activity. The identification of a deubiquitination pathway regulating NLRP3 …

2020年10月27日 · ABRO1, a subunit of the BRCC36 isopeptidase complex (BRISC), competes with WWP2 to bind to BRCC3, thereby preventing WWP2-mediated BRCC3 ubiquitination and …

2021年10月6日 · In particular, NLRP3 activation requires the deubiquitination of its LRR domain by the JAMM domain-containing Zn 2+ metalloprotease deubiquitinase (DUB) BRCC3 4. …

2025年2月8日 · The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells. BRCC3 mediates …

Ultimately, BRCC3 was identified as a key DUB based on the DUBscore, which was significantly overexpressed in tumour tissues, as confirmed by qRT‒PCR and immunohistochemistry …

2024年12月1日 · For instance, BRCC3 acts as a DUB that regulates the activity of NLRP3. Additionally, ubiquitin antibodies targeting K48 and K63 can cause immunoprecipitation …

2016年8月15日 · It has recently been shown that the DUB BRCC3 profoundly promotes inflammasome activation by deubiquitinating NLRP3, whereas the level of BRCC3 does not …

BRCA1/BRCA2-containing complex 3 (BRCC3) is a Lysine 63-specific deubiquitinating enzyme (DUB) involved in inflammasome activity, interferon signaling, and DNA damage repair. …