2024年12月24日 · DUSP7 (Dual Specificity Phosphatase 7) is a Protein Coding gene. Diseases associated with DUSP7 include Variola Major. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and MAPK family signaling cascades.

DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 -like (CH2) domain.

双特异性磷酸酶 (DUSP) 构成了 I 型基于半胱氨酸的蛋白酪氨酸磷酸酶超家族的一个大的异质亚群。 DUSP 的特征在于它们能够使酪氨酸和丝氨酸/苏氨酸残基去磷酸化。 DUSP7 属于一类 DUSP，称为 MKP，可使 MAPK (丝裂原活化蛋白激酶) 蛋白 ERK (参见 MIM 601795) 、JNK (参见 MIM 601158) 和 p38 (参见 MIM 600289) 去磷酸化，具有不同于个体的特异性 MKP 蛋白。 MKP 包含一个高度保守的 C 端催化结构域和一个 N 端 Cdc25 (参见 MIM 116947) 样 (CH2) 结构域。

DUSP7 inhibits cervical cancer progression by inactivating the RAS pathway. DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of ...

Here, we have identified the dual-specificity phosphatase 7 (DUSP7), known to display selectivity for ERK2, as important in regulating chromosome alignment. During mitosis, DUSP7 bound to ERK2 and regulated the abundance of active phospho-ERK2 through its phosphatase activity.

Here, we have identified the dual-specificity phosphatase 7 (DUSP7), known to display selectivity for ERK2, as important in regulating chromosome alignment. During mitosis, DUSP7 bound to ERK2 and regulated the abundance of active phospho-ERK2 through its phosphatase activity.

Title: DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of early arthritis.

J Cardiovasc Transl Res. 2022 Dec;15 (6):1217-1218. doi: 10.1007/s12265-022-10274-5. Epub 2022 May 19. 1 Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, 200444, China.

2016年10月25日 · The mechanisms that abrogate the prophase arrest in mammalian oocytes and reinitiate meiosis are not well understood. Here, we identify and characterize an essential pathway for the resumption of meiosis that relies on the protein phosphatase DUSP7. DUSP7-depleted oocytes either fail to resume meiosis or resume meiosis with a significant delay.

与人类DUSP7 (双特异性磷酸酶7)有同源性。 [由基因组资源联盟，2022年4月提供] Lineage-specific biology revealed by a finished genome assembly of the mouse. 预测能够激活MAP激酶酪氨酸/丝氨酸/苏氨酸磷酸酶活性和蛋白质酪氨酸/苏氨酸磷酸酶活性。 预测参与MAP激酶活性的负调控和肽基-酪氨酸脱磷酸化。 预测在细胞质中活性。 与人类DUSP7 (双特异性磷酸酶7)有同源性。 [由基因组资源联盟，2022年4月提供]