2009年2月1日 · We herein report the development of a HAC vector containing the entire human dystrophin gene (DYS-HAC) that is stably maintained in mice and human immortalized mesenchymal stem cells (hiMSCs).

2025年1月13日 · Previously, we generated transchromosomic mice carrying the full-length human dystrophin gene on a human artificial chromosome (DYS-HAC1) vector. The human dystrophin derived from DYS-HAC1...

The DYS-HAC vector contains the enhanced green fluorescent protein (EGFP) gene, the herpes simplex virus thymidine kinase (HSV-tk) gene, and several selection markers (bsd, puromycin, and HPRT...

Using microcell-mediated chromosome transfer, the DYS-HAC vector was transferred to the mdx-iPS cells, where it restored dystrophin expression in the teratomas that grew from the cells, as well as in chimeric mice derived from such cells, demonstrating the potential of the combined therapy for DMD.

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In this study, we investigated the hypothesis that simultaneous intravenous delivery of two rAAV vectors containing a short region of homology within the minidystrophin ΔH2–R19 gene would allow for reconstitution of a larger gene in vivo within the mdx4cv mouse model of DMD and protect myofibers from degeneration.

2024年7月17日 · We identified several split intein pairs that efficiently join two or three fragments to generate a large midi-dystrophin or the full-length protein. We show that delivery of two or three AAVs into...

Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin. We tested the ability of lentiviral vectors to deliver a transgene into myogenic cells before their transplantation.

The DYS-HAC vector, hybridized to the digoxigenin-labeled human Cot1 DNA probe (red), is indicated with an arrowhead. The dystrophin gene hybridized to the biotin-labeled bacterial artificial...

通过定义与 dys 方法相关的新能量递减函数，我们在 $f$、$g$ 和 $h$ 是半代数的额外假设下建立了整个序列的全局收敛和局部收敛率。 我们还为生成序列的有界性提供了充分条件。