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大家好，本期给大家分享的主题是与细胞周期密切相关的 e2f转录因子 家族知识。 e2f转录因子可以通过严格控制细胞周期、维持基因组完整性以及应对 复制压力 和 dna 损伤，在预防肿瘤发生方面发挥着重要作用。 感兴趣的小伙伴可以花一些时间阅览肯定会有所收获。

在e2f的靶点中有两个e型细胞周期蛋白(e1和e2，统称为细胞周期蛋白e)，它们结合并激活cdk2。cyclin e-cdk2负责完成rb1的磷酸化，通过释放更多的e2f，促进细胞进入s期所需的蛋白质的合成。

E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes.Three of them are activators: E2F1, 2 and E2F3a.Six others act as repressors: E2F3b, E2F4-8.All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the TTTCCCGC (or slight variations of this sequence) consensus binding site in the target ...

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e2f是一组编码高等真核生物 转录因子家族的基因。 其中三个是激活剂：e2f1,e2f2和e2f3a。其他六个充当抑制剂：e2f3b,e2f4,e2f5,e2f6,e2f7a,e2f7b和e2f8。它们都参与哺乳动物细胞中dna的细胞周期调控和合成。 e2f作为转录因子与目标启动子序列中的 tttcccgc共有结合位点结合，tttcccgc并不是固定序列，可能存在 ...

Dec 24, 2024 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma.Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Mitotic G1 phase and G1/S transition.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and ...

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May 11, 2021 · E2F transcription factor 2 (E2F2) is a member of the E2F family of transcription factors. The classical view is that some E2Fs act as "activators" and others "inhibitors" of cell cycle gene expression. However, the so-called "activator" E2F2 is particularly enigmatic, with seemingly contradictory ro …

Schematic representation of the E2F transcription factor subgroups, their physiological roles and specific binding partners. (A) The E2F family is divided into at least four subgroups defined by their regulation by pocket proteins and chromatin modifiers, and by their physiological function (i.e. activation or repression).See text for details.