2023年6月13日 · Specifically, E2F1, E2F2, and E2F3 enhance CDK1 transcription by binding to the positive-acting E2F site in the CDK1 promoter, which results in increased CDK1 expression 51. Mortality...

2022年3月31日 · RB-E2F complexes downregulate transcription via binding to E2F binding sites in the promoters of target genes. Taken together, this sequence of events constitutes the p53-p21-RB signaling ...

在e2f的靶点中有两个e型细胞周期蛋白(e1和e2，统称为细胞周期蛋白e)，它们结合并激活cdk2。cyclin e-cdk2负责完成rb1的磷酸化，通过释放更多的e2f，促进细胞进入s期所需的蛋白质的合成。

2022年10月10日 · Inhibition of CDK1/CDK2 prevented DNA damage induced by E2F loss, suggesting that E2F1/E2F2 safeguard genome integrity by restraining CDK1/CDK2 activity. Importantly, combined inhibition of E2F and ATR boosted replication stress and dramatically reduced tumorigenic capacity of PCa cells in xenografts.

2019年5月3日 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, how misexpression...

最后，在g1晚期，转录因子e2f激活早期有丝分裂抑制因子 emi1的转录，该蛋白可以作为假底物抑制apc/c的活性。 图6 APC/C-Cdh1可以抑制细胞进入S期， 从而在G1期滞留

2016年3月23日 · The up-regulation of E2F1, CDK1 and cleaved caspase-9 was significantly attenuated by the systemic injection of CR8 (1mg/kg/day, intraperitoneally) starting at 5min after deafening. These findings indicate that the activation of the E2F1-CDK1 pathway and cell cycle re-entry contributes to the apoptosis of SGCs and that the selective inhibition ...

在 g1 阶段，抑癌基因 rb 结合并抑制转录因子 e2f。 在 G1 末期被周期素依赖性激酶 (CDK) 磷酸化的 Rb 会诱使 Rb 分裂，并允许 E2F 介导的 S 期促进基因的转录。

Here we present evidence that combined silencing of E2F1 and E2F2 results in inappropriate CDK1 activation during S phase, concomitantly with reduced expression of WEE1, an E2F target gene encoding the CDK1/2 inhibitory kinase WEE1 .

2023年1月30日 · Tumor suppressor RB binds to E2F family proteins and modulates cell cycle progression. Cyclin dependent kinases (CDK) regulate the interaction of RB/E2F by phosphorylating RB. Previously, we have revealed that CDK2, RB and E2F inhibit ferroptosis. Ferroptosis is a non-apoptotic, iron-dependent form …