2024年12月24日 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma.Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Mitotic G1 phase and G1/S transition.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and ...

1869 13555 Ensembl ENSG00000101412 ENSMUSG00000027490 UniProt Q01094 Q61501 RefSeq (mRNA) NM_005225 NM_007891 NM_001291105 RefSeq (protein) NP_005216 NP_001278034 NP_031917 Location (UCSC) Chr 20: 33.68 – 33.69 Mb Chr 2: 154.4 – 154.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. Function The ...

转录因子e2f1是由人类e2f1基因编码出的蛋白质 [1] 。 该基因编码出的蛋白质是e2f转录因子家族中的成员。e2f家族在控制细胞周期及抑癌基因功能上起到重要作用，也是小dna致癌病毒转化蛋白的靶点。e2f家族中的多个成员蛋白包含许多进化保守的结构域。

乳腺癌小鼠模型中，e2f1和e2f2调节是对血管生成、细胞外基质重塑和肿瘤细胞与内皮细胞之间的相互作用至关重要的一组基因表达。 因此，E2Fs失调不仅通过调节细胞周期和基因组稳定性来促进肿瘤发展的早期阶段，而且还可以推动良性肿瘤向恶性转移癌的发展。

2017年11月10日 · The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and reviewed before; however, here, we focus on the participation of E2F1 in the regulation of metabolism. We summarize recent findings about the cell ...

转录因子e2f1 是由人类 e2f1 基因 编码出的蛋白质。该基因编码出的蛋白质是e2f转录因子家族中的成员。e2f家族在控制细胞周期及抑癌基因功能上起到重要作用，也是小dna致癌病毒转化蛋白的靶点。e2f家族中的多个成员蛋白包含许多进化保守的结构域。

e2f 转录因子 1： 该基因编码的蛋白质是 e2f 转录因子家族的成员。 e2f 家族在控制细胞周期和肿瘤抑制蛋白的作用中起着至关重要的作用，也是小 dna 肿瘤病毒转化蛋白的靶标。 e2f 蛋白包含几个在大多数家族成员中发现的进化保守结构域。这些结构域包括 dna 结合结构域、决定与分化调节 …

The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required. Altered tumor suppressor and oncogenic signaling pathways often result in direct or indirect interference with E2F1 regulation ...

Cell cycle-dependent regulation of E2F1. (A) It is hypothesized that the E2F1–DP1 heterodimer can mediate proliferation versus apoptosis depending on the cellular levels of E2F1 and its post-translational modifications.Upon mitogenic stimulation binding of pRB is reduced and E2F1 can enhance transcription of cell cycle target genes.

2019年5月3日 · Methylation of E2F1 at Lys185 has several far-reaching effects on E2F1 including promotion of neddylation at the same residue, inhibition of acetylation and phosphorylation at distant positions ...