2024年12月24日 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Mitotic G1 phase and G1/S transition.

E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as repressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.

乳腺癌小鼠模型中，e2f1和e2f2调节是对血管生成、细胞外基质重塑和肿瘤细胞与内皮细胞之间的相互作用至关重要的一组基因表达。 因此，E2Fs失调不仅通过调节细胞周期和基因组稳定性来促进肿瘤发展的早期阶段，而且还可以推动良性肿瘤向恶性转移癌的发展。

1869 13555 Ensembl ENSG00000101412 ENSMUSG00000027490 UniProt Q01094 Q61501 RefSeq (mRNA) NM_005225 NM_007891 NM_001291105 RefSeq (protein) NP_005216 NP_001278034 NP_031917 Location (UCSC) Chr 20: 33.68 – 33.69 Mb Chr 2: 154.4 – 154.41 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene. Function The ...

2014年12月5日 · We mapped the interaction between E2F1 and FOXO3 to a region including the DNA binding domain of E2F1 and the C-terminal transcription-activation domain of FOXO3. We propose that E2F1 inhibits FOXO3-dependent transcription by directly binding FOXO3 in the nucleus and preventing activation of its target genes.

2024年9月1日 · The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes, plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging, angiogenesis, tumor promotion or suppression, and other biological processes.

利用GTRD，在transcription factor target genes中选择物种（organism）：Human；转录因子（transcription factor）：E2F1 QO1094；转录因子结合位点（TF binding site location）：Promoter [-1 000，+100]，得到E2F1调控靶基因并从中筛选保留靶基因中的miRNA，设为GTRD-miRNAs数据集。

2015年12月3日 · Our results represent the first crystal structure of an E2F protein with two DBDs, and reveal the mechanism by which atypical E2Fs can repress canonical E2F target genes and exert their negative...

2015年2月6日 · We show that inactivation of E2F1 and E2F2 results in accumulation of DNA replication mediators, activation of the DNA damage response (DDR) and induction of p53-dependent apoptosis. Genetic...

2002年6月21日 · The elimination of immature and mature autoreactive T cells via apoptosis is an essential mechanism to prevent autoimmunity. E2F1 has been shown to play a critical role in the elimination of self-reactive immature T cells during thymic negative selection [146], [154], [155].