研究发现，apoe是65岁后发的迟发型 阿尔兹海默症 （ad）的主要风险因子，其中apoe*ε2对ad有保护作用，apoe*ε4会增强ad发病风险。 携带的APOE基因型比例也会影响患AD概率，比如携带一个APOE*ε4患AD风险提高3-4倍，而同时携带两个APOE*ε4的患病风险则提高9-15倍。

2019年3月20日 · Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor of AD, is expressed in more than half of AD patients and is thus an important possible AD therapeutic target. This review focuses initially on the pathological effects of apoE4 in AD, as well as on the corresponding cellular and animal models and the suggested cellular and ...

APOE-ε4 is the strongest genetic risk factor for Alzheimer’s disease (AD), and is associated with an increase in the levels of amyloid deposition and an early age of onset. Recent data demonstrate that AD pathological changes occur decades before clinical symptoms, raising questions about the precise onset of the disease.

2024年6月19日 · Alzheimer’s disease (AD) is a complex, progressive primary neurodegenerative disease. Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) has remained the...

APOE polymorphic alleles are the main genetic determinants of Alzheimer disease (AD) risk: individuals carrying the ε4 allele are at increased risk of AD compared with those carrying the more common ε3 allele, whereas the ε2 allele decreases risk.

2024年1月8日 · Here, we review these scientific advances and propose a cell type-specific APOE4 cascade model of AD. In this model, neuronal APOE4 emerges as a crucial pathological initiator and driver of AD...

apoe4是一种促进迟发型ad风险的强遗传因子，应激或损伤可诱导神经元内apoe表达。先前已有研究证据表明神经元apoe4是ad相关过程的关键因子，如抑制性神经元和记忆的丧失，以及tau蛋白的磷酸化。

2024年5月6日 · This study aimed to evaluate the impact of APOE4 homozygosity on Alzheimer’s disease (AD) by examining its clinical, pathological and biomarker changes to see whether APOE4 homozygotes ...

2020年4月30日 · 其中ApoE4（载脂蛋白E4）的遗传变异被确定为阿尔茨海默氏病的主要危险因素，也是已知的最强的遗传危险因素。 研究表明ApoE4加重血脑屏障损伤和脑毛细血管周细胞变性。

2024年5月10日 · They compare E4 homozygotes with autosomal-dominant Alzheimer’s (ADAD) and Down’s syndrome AD (DSAD). But there are some subtle differences that we should remember. ADAD has a more aggressive presentation and regional accumulation of Aβ is more marked in the striatum, cerebellum (and in some cases in the cortico-spinal tracts, resulting in ...