E47 phosphorylation by p38 MAPK promotes MyoD/E47 …
Phosphorylation of E47 at Ser140 by p38 induces MyoD/E47 association and activation of muscle-specific transcription, while the nonphosphorylatable E47 mutant Ser140Ala fails to …
TCF3 - Wikipedia
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. [5][6][7] TCF3 has been …
HMS E47 - Wikipedia
HMS E47 was an E-class submarine launched by Fairfield, Govan for the Royal Navy and completed by William Beardmore, Dalmuir. She was launched on 29 May 1916 and was …
核转录因子E47的功能研究进展 - Magtech
2025年3月23日 · 摘要： E47是一个碱性螺旋环螺旋(Basic Helix-Loop-Helix,bHLH)蛋白,作为真核生物的一个重要转录因子,它参与了细胞周期调控,促进细胞衰老;调控胰岛素和胰高血糖素基因 …
E47 as a novel glucocorticoid-dependent gene mediating lipid …
2023年11月17日 · E47 has been identified as a modulating transcription factor of glucocorticoid receptor target genes, its loss protecting mice from metabolic adverse effects of glucocorticoids.
E47 modulates hepatic glucocorticoid action - PMC - National …
2019年1月18日 · We identify the bHLH factor E47 as a modulator of GR target genes. Using mouse genetics, we find that E47 is required for the regulation of hepatic glucose and lipid …
Gene expression patterns define novel roles for E47 in cell cycle ...
The data presented here identify previously unrecognized E47 target genes that may provide insight into how E47 acts to regulate cell cycle progression, cytokine-mediated signaling, lipid …
Helix-loop-helix transcription factor E47 activates germ-line ...
E47 is a helix-loop-helix transcription factor that binds to sites in the immunoglobulin heavy-chain and kappa light-chain gene enhancers. Other proteins of this type are involved in cell-type …
Enforced expression of E47 has differential effects on Lmo2-induced …
2015年1月1日 · We address the paradigm that E47 deficiency is the mechanism by which Lmo2 induces T-ALL. Enforced E47 homodimerization causes G1 arrest in some but not all Lmo2 …
研究人员取得新进展胰腺癌细胞可分化为正常细胞-齐一生物报
2015年4月22日 · e47蛋白质数量的增加引起细胞停滞在g0/g1（细胞停止分裂与dna合成前期）增长阶段，并分化回腺泡细胞表型。 活体研究表明，重新编码的肿瘤细胞引入到小鼠时，形成 …