2011年4月3日 · Our results indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in T H 1 cells and IL-10 in T H 1 cells, T H 2 cells, T reg cells and NKT cells. After being...

2009年9月13日 · Here we show that the basic leucine zipper (bZIP) transcription factor E4BP4 (also called NFIL3) is essential for generation of the NK cell lineage. E4BP4-deficient mice (Nfil3−/–; called '...

2012年2月1日 · E4BP4 is essential for the development of NK cells and CD8α + conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4 + T cell responses and B cell class switching to IgE. Here, we discuss the role of E4BP4 as a regulator of the immune response and highlight future questions for the field. What is E4BP4?

2024年5月7日 · We show that E4BP4 binds the Il4ra gene, which promotes anti-inflammatory properties, and enhances Il4ra expression and chromatin accessibility to ELF4, a transcription factor that suppresses...

E4BP4, a mammalian basic leucine zipper (bZIP) transcription factor, was first identified through its ability to bind and repress viral promoter sequences. Subsequently, E4BP4 and homologues in other species have been implicated in a diverse range of …

2020年6月29日 · 腺病毒e4启动子结合蛋白-4（e4bp4）是哺乳动物细胞核内的一种碱性亮氨酸拉链 (bzip) 型转录因子,参与调控细胞的存活和增殖【6】。已有研究表明e4bp4参与调节免疫细胞谱系的发育和功能，还可以调节b细胞的ige类别转换，t细胞极化反应和细胞因子的表达【7-10】。

E4BP4 is essential for the development of NK cells and CD8α (+) conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4 (+) T cell responses and B cell class switching to IgE. Here, we discuss the role of E4BP4 as a regulator of the immune response and highlight future questions for the field.

2024年5月7日 · We show that macrophage-specific upregulation of the clock output gene and transcription factor E4BP4 reduces the severity of colitis in mice. RNA-sequencing and single-cell analyses of macrophages revealed that increased expression of E4BP4 leads to an overall increase in expression of anti-inflammatory genes including Il4ra with a concomitant ...

E4BP4 strongly suppresses Fgf21 transcription by binding to a D-box element in the distal promoter region. Depletion of E4BP4 in synchronized Hepa1c1c-7 liver cells augments the amplitude of Fgf21 expression, and overexpression of E4BP4 represses FGF21 secretion from primary mouse hepatocytes.

2017年7月1日 · E4BP4 is a basic leucine zipper transcription factor. E4BP4 serves as a key regulator in the development and functions of immune cells. E4BP4 plays a crucial role in various immune-mediated diseases.