In summary, current data suggest an overall decrease in EAAT1 mRNA in affective disorders, while an increase in EAAT1 mRNA and decrease in EAAT1 protein is associated with schizophrenia; results which are further complicated by suicide completion and medication use.

EAAT1 is highly expressed in the neocortex and cerebellum, especially in astrocytes [2,19]; EAAT2 is the main glutamate transporter found in the forebrain; it is abundantly expressed in astrocytes and in a limited extent also on presynaptic nerve terminals [2,20].

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels at low levels. In physiology, this is essential for the rapid ...

2010年3月16日 · Excitatory amino acid transporters (EAATs) appear to participate in the pathogenesis of neuropathic pain. The present study was performed to evaluate the effects of the tricyclic antidepressant amitriptyline on the expressions of EAATs in neuropathic pain rats.

2017年4月19日 · Here we present crystal structures of a thermostabilized human SLC1 transporter, the excitatory amino acid transporter 1 (EAAT1), with and without allosteric and competitive inhibitors bound.

2019年12月15日 · Pharmacological inhibition or gene knock-down of spinal GluTs can induce/aggravate pain, whereas enhancing expression of GluTs by viral gene transfer can mitigate chronic pain. Thus, functional up-regulation of GluTs is turning into a prospective pharmacotherapeutic approach for the management of chronic pain.

2022年1月6日 · Excitatory amino acid transporters (EAATs) optimize the temporal resolution and energy demand of mammalian excitatory synapses by quickly removing glutamate from the synaptic cleft into surrounding neuronal and glial cells …

2005年6月29日 · We looked for mutations in SLC1A3, which encodes the glutamate transporter excitatory amino acid transporter (EAAT) 1 that is important in removing glutamate from the synaptic cleft.

2010年3月16日 · Excitatory amino acid transporters (EAATs) appear to participate in the pathogenesis of neuropathic pain. The present study was performed to evaluate the effects of the tricyclic antidepressant amitriptyline on the expressions of EAATs in neuropathic pain rats.

2024年6月4日 · In this sense, downregulation or inhibition of EAATs has been reported to increase pain , whereas increased EAAT2 expression can mitigate pain [204, 205, 206]. For example, overexpression of GLT-1 in the spinal cord attenuated the induction of inflammatory and neuropathic pain, suggesting this could be a strategy for pain [ 207 ].