2019年2月15日 · LHX2 and another transcription factor EBF cooperatively bind particular motifs within euchromatin enhancer regions termed “Greek islands,” that evade heterochromatic silencing. Several intergenic enhancers need to interact in trans to form interchromosomal hubs that can initiate the expression of a particular OR ( Monahan et al., 2017 ).

We investigated whether the transcription factors Lhx2 and Ebf regulated OR enhancer accessibility and found that Lhx2 expression highly correlated with enhancer accessibility in our single-cell...

2019年6月1日 · LDB1 is recruited to olfactory receptor gene enhancer hubs by LHX2 together with EBF and promotes specific inter-chromosomal contacts between the individual enhancers. This novel inter-chromosomal enhancer ‘hub’, or compartment, is essential for odorant receptor gene choice and is dependent on LDB1.

2019年1月9日 · The Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor...

2021年10月1日 · For the NEUROD1 sites, we found enrichment for EBF and LHX motifs, which could correspond to the neurogenic TFs EBF3 and LHX8 that show higher expression in the NEUROD1 subtype.

(C) Lhx2/Ebf bound Greek Islands form an interchromosomal, multi-enhancer hub that recruits coactivators essential for the de-silencing of OR promoters and robust transcriptional activation of...

2022年1月12日 · Through integrative analysis and genetic manipulations, we found that transcription factors E2F4, TEAD1 and AP-1 are key regulators of RS. Overexpression of E2f4 improved cellular proliferative capacity, attenuated SA-β-Gal activity and changed RS-associated differentially methylated sites (DMSs).

Sets of sites comprising Greek Islands with a strong composite motif, Greek Islands without a strong composite motif, Ebf and Lhx2 co-bound sites genome-wide, and OR gene promoters are compared....

预测可实现 DNA 结合转录激活因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。 预测参与 RNA 聚合酶 II 对转录的正调控。 预测作用于转录正调控的上游或正调控内，DNA 模板化。 预测位于核内。 预测是染色质的一部分。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity.

2023年1月11日 · NEUROD1 binding motif was enriched for EBF and LHX motifs corresponding to the higher expression of TFs EBF and LHX in NEUROD1 subtype. Gene set enrichment analyses to identify pathways represented in ASCL1 and NEUROD1 subtypes showed that ASCL1 subtype was enriched in GO pathways of response to cytokines …