Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). [1] It is the only EBV protein found in all EBV-related malignancies. [2] [3] It is important in establishing and maintaining the …

Epstein-Barr nuclear antigen 1 (EBNA1) was the first Epstein-Barr virus (EBV) protein detected and is the most widely studied [1]. EBNA1 is expressed in both latent and lytic modes of EBV infection, although it has mainly been studied in latency, where it plays multiple important roles.

Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as for maintaining the genome as an ...

2018年4月6日 · The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby …

2019年9月11日 · The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA damage and...

1994年10月17日 · Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as …

2024年4月2日 · The pathogenesis of multiple sclerosis may involve intrathecal Epstein-Barr virus nuclear antigen-1 (EBNA-1) specific T cells susceptible to modulation by vitamin D. These results provide evidence that EBNA1 is a new target for the transcription factor HSF1.

EBNA-1, encoded by Epstein-Barr virus (EBV), is a multifunctional protein essential for both EBV's extrachromosomal replication and positive and negative regulation of multiple viral promoters (9, 15, 32).

ebna-1是ebv潜伏感染时编码的一种核蛋白,它能调节ebv基因的复制,增强病毒基因的转录,并能保证ebv以附加体的形式稳定存在于被感染的细胞内。 利用此蛋白上述两种功能特点,研究者构建了EBV复制子载体,这种载体已被广泛地应用于基因治疗。

2016年10月8日 · EBNA-1 is a direct DNA-binding protein, and both replication and transactivation are dependent on the interaction of EBNA-1 with its cognate DNA recognition sequences. To better understand EBNA-1 function, we have further characterized the DNA-binding domain of EBNA-1 and have examined the contributions of other domains of the protein to EBNA-1 ...