Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV). [1] It is the only EBV protein found in all EBV-related malignancies. [2][3] It is important in establishing and maintaining …

Epstein-Barr nuclear antigen 1 (EBNA1) was the first Epstein-Barr virus (EBV) protein detected and is the most widely studied [1]. EBNA1 is expressed in both latent and lytic modes of EBV infection, although it has mainly been studied in latency, where it plays multiple important roles.

Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA ...

Using only three parameters [viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA)-1 IgG],it is normally possible to distinguish acute from past infection: the presence of VCA IgM and VCA IgG without EBNA-1 IgG indicates acute infection, whereas the presence of VCA IgG and EBNA-1 IgG without VCA IgM is typical of past infection.

2019年9月11日 · The EBV nuclear antigen (EBNA)-1 induces the accumulation of reactive oxygen species (ROS), which enables B-cell immortalization but causes oxidative DNA damage and triggers...

1994年10月17日 · Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as …

The Epstein–Barr virus (EBV) nuclear antigen (EBNA)-1 is the only viral protein expressed in all EBV-carrying malignancies, but its contribution to oncogenesis has remained enigmatic. We show that ...

12 小时之前 · 编辑推荐： 为探究 EBV 感染及传染性单核细胞增多症（IM）后能否用血清学指标预测多发性硬化（MS），研究人员检测相关抗体，发现高抗 EBNA-1 IgG 水平与 MS 风险显著相关，高抗 VCAp18 IgG 水平相关性较弱，这为 MS 诊断提供新方向。

2018年4月6日 · The presence of the Epstein-Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) protein in all EBV-carrying tumours constitutes a marker that distinguishes the virus-associated cancer cells from normal cells and thereby offers opportunities for targeted therapeutic intervention. EBNA1 is essential fo …

2021年2月3日 · 近日，来自美国费城威斯达研究所的 Paul M. Lieberman 研究组在 Cell 杂志上发表了一篇题为 Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance 的文章， 揭示了EBNA1通过与DNA交联促进在oriP位点的复制终止实现附加体维持的具体分子机制。 EB病毒长期潜伏感染，会增加癌症和自身免疫疾病的风险 【1-3】。 EBNA1是潜伏感染期间病毒DNA复制和附加体维持所需的唯一病毒蛋白【4】。