Epstein–Barr virus (EBV) is an extremely efficient virus infecting the majority of the world’s adult population (Rickinson and Kieff, 2001). Following primary infection, EBV persists in the infected host as a lifelong asymptomatic infection.

Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease ...

There are two main EBV genotypes, Type 1 and 2, distinguished by the differences in the EBNA-2 gene. Further sub genotyping can be characterized by analyzing the LMP-1 gene variation. The virus primarily transmits through oral secretions and persists as a …

2022年9月15日 · Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies.

2019年9月2日 · Epstein–Barr virus (EBV) was the first tumour virus identified in humans. The virus is primarily associated with lymphomas and epithelial cell cancers. These tumours express latent...

2017年4月24日 · EBV-DNA 阳性是 EBV 存在的直接证据。 由于潜伏感染的存在，正常人外周血单个核细胞中也常有低载量的 EBV-DNA 检出（通常低于 200 拷贝数/mL）。 在活动感染发生时 EBV 在人淋巴细胞中大量增殖（IM 患者一般可达 10 3 ～10 5 拷贝数/mL）并释放到血浆或淋巴液中。 随着感染的控制，EBV 感染进入潜伏状态，血浆或淋巴液中的病毒颗粒迅速消失，而外周血淋巴细胞中的 EBV 仍将以潜伏状态保持较高滴度数月～1 年。 对于复发性感染外周血 EBV-DNA 载 …

2019年6月14日 · IMPORTANCE Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) is a useful model system to study EBV oncogenesis. By incorporating transcriptome sequencing (RNA-seq), chromatin immune precipitation followed by deep sequencing (ChIP-seq), chromatin interaction analysis followed by paired-end tag sequencing (ChIA-PET), and ...

2022年9月29日 · Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies.

EBV-encoded latent genes are set of viral genes that are expressed in latently infected cells. They include virally encoded proteins, noncoding RNAs, and microRNAs. Different latent gene expression patterns are noticed in different types of EBV-infected cells.

To achieve long-term persistence in vivo, EBV colonizes the memory B-cell pool where it establishes latent infection, which is characterized by the expression of a limited subset of virus genes, known as the “latent” genes (Thorley-Lawson, 2001).