Posttransplant lymphoproliferative disease (PTLD) is a potentially fatal complication after (solid organ) transplantation, which is highly associated with Epstein-Barr virus (EBV). The EBV-specific cytotoxic T cell response that is essential in controlling the virus in healthy individuals is suppressed in transplant recipients using ...

PTLD are a heterogeneous spectrum of predominantly B-cell disorders, often extra-nodal, with complex distinct pathogeneses and variable clinical presentations determined by pathologic subtype. Recent epidemiologic studies report a decrease in early EBV-positive (+) PTLD and an increase in late EBV-negative (-) PTLD.

2023年7月10日 · PTLD is a proliferative B-cell disorder that is associated with the Epstein-Barr virus (EBV). It can be acquired either as a result of primary infection (frequently), from the donor or environmental exposure. EBV-negative PTLD occurs in approximately 23% of patients.

2018年2月7日 · Recipients of solid-organ or allogeneic hematopoietic stem-cell transplants have an increased risk of cancers related to immunosuppression and the Epstein–Barr virus (EBV) — in particular,...

Management of Epstein-Barr virus post-transplant lymphoproliferative disorder (EBV PTLD) is complex, involving risk stratification, prevention and/or pre-emptive measures involving monitoring EBV DNAemia and balancing treatment options, using a combination of reduction of immune suppression, anti-B cell therapy, and cytotoxic T lymphocytes (CTLs).

Epstein-Barr virus (EBV)–driven B-cell lymphoproliferation represents the prototype of quintessential PTLD, which includes a range of histologies named nondestructive, polymorphic, and monomorphic EBV + diffuse large B-cell lymphoma (DLBCL) PTLD.

2019年5月14日 · This article aims to explore the entity of EBV-PTLD in HSCT recipients, expanding on clinical presentation, risk factors, modes of monitoring and treatment, and so highlighting the gaps in ...

EBV is known to play a major role in the development of PTLD (4). The pathogenesis of these disorders is complex, and related to EBV’s ability to transform and immortalize B lymphocytes, sometimes combined with secondary genetic or epigenetic …

2022年9月1日 · Epstein-Barr Virus (EBV) is involved in a substantial number of cases. In this review, we aim to summarize recent knowledge on pathogenesis, classification and treatment of EBV + PTLD. Recent findings: New insights in the complex oncogenic properties of EBV antigens noncoding Ribonucleic acids (RNAs), especially EBV MicroRNA (miRNAs), have ...

ptld是造血干细胞移植及实体器官移植后的一种严重并发症，其发生绝大多数与ebv感染关系密切。ptld的诊断主要依据为临床表现、外周血ebv载量和病理结果。ptld应进行分级诊断和分级治疗。