2022年2月1日 · Infection with Epstein-Barr virus dramatically increased the odds of developing multiple sclerosis. The finding suggests that vaccines against the virus could help prevent …

2022年8月5日 · Here we review the evidence that EBV is a causal agent for MS and how various risk factors may affect EBV infection and immune control. We focus on EBV contributing to MS through...

The study, published Jan. 24 in Nature, shows that approximately 20% to 25% of patients with multiple sclerosis have antibodies in their blood that bind tightly to both a protein from the Epstein-Barr virus, called EBNA1, and a protein made in the brain and spinal cord, called the glial cell adhesion molecule, or GlialCAM.

2023年2月9日 · In this Review, we discuss the evidence linking EBV to the development of MS and the mechanisms by which the virus is thought to cause the disease. Furthermore, we discuss implications for the...

2024年6月2日 · Strong evidence shows that viruses can trigger the process, especially Epstein-Barr virus (EBV). This research may guide scientists toward new and better ways to treat or …

2022年1月13日 · In at-risk individuals, Epstein-Barr virus (EBV) infection of B cells promotes the development of multiple sclerosis through several possible mechanisms. These include molecular mimicry (1) by EBV nuclear antigen 1 (EBNA-1), B cell transformation (2) through latent membrane protein 1 (LMP1) and LMP2A, induction of B cell trafficking (3) to the ...

2022年8月5日 · Here we review the evidence that EBV is a causal agent for MS and how various risk factors may affect EBV infection and immune control. We focus on EBV contributing to MS through reprogramming of latently infected B lymphocytes and the chronic presentation of viral antigens as a potential source of autoreactivity through molecular mimicry.

2022年1月25日 · New data published in Science provide robust evidence that Epstein–Barr virus (EBV) infection can cause multiple sclerosis (MS). The findings strengthen the case for rapid development of a...

2 天之前 · Where does Epstein Barr virus (EBV) reside in the MS patient? There are likely several sites. It lies dormant in peripheral lymph glands. Indeed, the proposed mechanism of fingolimod and this class of drug (S1P) works by sequestering latent EBV-infected B cells within the peripheral lymph nodes (Chun and Hartung 2010). Other possible sites include bone marrow (Farrell et al 2019), CSF B- cell ...

3 天之前 · Keywords: multiple sclerosis, Epstein-Barr virus Case Report The epidemiological link between multiple sclerosis (MS) and the Epstein-Barr virus (EBV) is well-established 1, but the role of EBV in MS pathology and clinical progression remains controversial.