Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. [5][6][7] Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides. [5] ^ "Human PubMed Reference:".

2024年12月24日 · ECE1 (Endothelin Converting Enzyme 1) is a Protein Coding gene. Diseases associated with ECE1 include Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction and Hypertension, Essential. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

1994年8月12日 · We report the identification of ECE-1, a novel membrane-bound neutral metalloprotease that is expressed abundantly in endothelial cells in vivo and is structurally related to neutral endopeptidase 24.11 and Kell blood group protein.

Data indicate endothelin-converting enzyme-1 (ECE-1) as a target for alternative polyadenylation (APA), a regulatory mechanism aberrantly activated in cancer cells, and the mechanisms leading to ECE-1 overexpression in malignant cells.

We report the identification of ECE-1, a novel membrane-bound neutral metalloprotease that is expressed abundantly in endothelial cells in vivo and is structurally related to neutral endopeptidase 24.11 and Kell blood group protein.

内皮素转化酶 1： 由该基因编码的蛋白质参与将内皮素前体蛋白水解加工成生物活性肽。 该基因的突变与先天性巨结肠、心脏缺陷和自主神经功能障碍有关。

2012年7月30日 · Endothelin Converting Enzyme-1 (ECE-1) plays a significant role in the regulation of vascular tone and hence blood pressure. It has also been implicated in the pathogenesis of cardiovascular diseases, female malignancies and Alzheimer’s disease. Four different isoforms of ECE-1 exist and have varying degrees of distribution throughout the cell.

内皮素转换酶-1 (ECE-1) 有助于激活内皮素-1 (ET-1)，内皮素-1 是一种有效的血管收缩剂和促纤维化物质。 这项研究阐明了 ECE-1 敲除对小鼠肾纤维化模型中与 ET-1 下调相关的影响。 使用单侧对 ECE-1 敲除 (ECE-1 KO) 和血管内皮源性 ET-1 KO (VEETKO) 小鼠（2 个月，20-30 g，n = 30）及其野生型 (WT) 同窝小鼠进行肾纤维化检查输尿管梗阻（UUO）手术。 UUO 后第 7 天和第 14 天对小鼠实施安乐死。 对纤维化和肾小管损伤进行组织病理学分析。 进行免疫染色以量化 …

2004年1月1日 · This chapter focuses on the structural chemistry of Endothelin-Converting Enzyme 1 (ECE-1). The ECE-1 is a type II integral membrane protein with a short N-terminal cytoplasmic tail, a transmembrane hydrophobic domain and a large extracellular domain containing the catalytic site and a zinc-binding motif (HEXXH).

MCE提供ECE-1 蛋白, Human (HEK293, His)，ECE-1 蛋白通过催化大内皮素-1 转化为内皮素-1，在血管调节中发挥关键作用。 这一酶促过程是内皮素-1 成熟的关键步骤，内皮素-1 是一种有效的血管收缩剂和信号分子，参与血压、血管张力和各种生理功能的调节。