Architecture and Membrane Interactions of the EGF Receptor
2013年1月31日 · Dimerization-driven activation of the intracellular kinase domains of the epidermal growth factor receptor (EGFR) upon extracellular ligand binding is crucial to cellular …
Structure and dynamics of the EGFR/HER2 heterodimer
2023年2月13日 · Here, we report cryo-EM structures of the EGF- and epiregulin-bound EGFR/HER2 ectodomain complexes at resolutions of 3.3 Å and 4.5 Å, respectively. Together …
Epidermal Growth Factor Receptor Dimerization and Activation …
Structural studies have shown that ligand-induced epidermal growth factor receptor (EGFR) dimerization involves major domain rearrangements that expose a critical dimerization arm. …
EGFR oligomerization organizes kinase-active dimers into ... - Nature
2016年10月31日 · Epidermal growth factor receptor (EGFR) signalling is activated by ligand-induced receptor dimerization. Notably, ligand binding also induces EGFR oligomerization, but...
Binding of single-mutant epidermal growth factor (EGF) ligands …
The MD simulations of the EGF mutants indicated that mutations had long-range effects on the receptor dimer interface. This study shows for the first time that a single mutation in the EGF is …
Mechanisms for Kinase-mediated Dimerization of the Epidermal …
We study a mechanism by which dimerization of the EGF receptor (EGFR) cytoplasmic domain is transmitted to the ectodomain. Therapeutic and other small molecule antagonists to the kinase …
The architecture of EGFR’s basal complexes reveals autoinhibition ...
2018年10月18日 · Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based on X-ray structural data of monomer and dimer receptor fragments and …
Ligand-independent Dimer Formation of Epidermal Growth …
Dimerization and phosphorylation of the epidermal growth factor (EGF) receptor (EGFR) are the initial and essential events of EGF-induced signal transduction. However, the mechanism by …
Different EGF-induced receptor dimer conformations for signaling …
2023年12月10日 · Here, we provide direct evidence that EGF-induced EGFR dimer formation as best illustrated by the very large increase in FRET between snap-tagged EGFR subunits …
Two EGF molecules contribute additively to stabilization of the EGFR dimer
1997年1月15日 · We have analyzed the binding of epidermal growth factor (EGF) to the extracellular domain of its receptor (sEGFR) using titration calorimetry, and the resulting …