Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. EGF activation of the EGFR induces receptor dimerization and transphosphorylation of the C-terminal domain.

Ras-Raf-MAPK通路 Ras 的活化开启了多步骤的磷酸化级联反应，最终激活撕裂原活化蛋白激酶，细胞外信号调节激酶 (ERK1)和ERK2。 ERK1和ERK2调与细胞增殖、存活、转化相关的转录分子，而 MAPK参与细胞周期调控。 b、磷脂酰三磷酸肌醇 (PI3K)和丝苏氨酸蛋白激酶 (AKT)通路: AKT的激活能激发一系列与细胞生存、抗凋亡有关的反应。 c、JAK 和 STAT 通路: JAK 是Janus 家族蛋白酪氨酸激酶，活化的 JAK通过信号转导与转录激活因子 (sigketransduction and …

2022年8月17日 · EGFR 通过与上皮生长因子（EGF）或转化生长因子 α（TGF-α）配体结合后激活其位于细胞内的激酶通路（ERK 1/2），从而诱导细胞增殖。 EGFR 是非小细胞肺癌（NSCLC）最为常见的驱动突变基因，主要的基因突变发生在其酪氨酸蛋白激酶（RTK）活性结构域（18-24 外显子间）上，其中又以 外显子 19 缺失（19del 45-46%）、外显子21 L858R突变（38-45%）最为常见。 图片来源：EGFR MUTATION.

2020年6月23日 · In this Review, we discuss the current understanding of this important class of kinases. We begin with a brief overview of the structure, regulation, substrate recognition and subcellular...

2013年1月24日 · The EGF-stimulated ERK/MAPK pathway is a key conduit for cellular proliferation signals and a therapeutic target in many cancers. Here, we characterize two central quantitative aspects of this pathway: the mechanism by which signal strength is encoded and the response curve relating signal output to proliferation.

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells. Reflecting this importance, it is one of the best-investigated ...

In COS-7 cells, α 2A-adrenergic receptors (ARs) stimulate ERK phosphorylation via two distinct pathways, a transactivation pathway that involves the release of HB-EGF and the EGFR and an alternate pathway that is independent of both HB-EGF and the EGFR. We have developed a mixed culture system to study the mechanism of GPCR-mediated HB-EGF ...

Many feedback loops are present in the EGF receptor (EGFR)-ERK network, but the mechanisms driving pulsatile ERK kinetics are unknown. Here, we find that in cells that respond to EGF with frequency-modulated pulsatile ERK activity, stimulation through a heterologous TrkA receptor system results in non-pulsatile, amplitude-modulated activation ...

2025年2月7日 · egfr（表皮生长因子受体）是一种受体酪氨酸激酶，其在多种癌症中异常激活，尤其是肺癌。egfr的激活能够通过下游的erk（细胞外信号调节激酶）信号通路调控细胞增殖、存活和迁移。

2021年4月1日 · We show that oncogene-driven signalling is strikingly limited without EGFR activity and insufficient to sustain full proliferative potential. In PDOs and in vivo, upstream EGFR activity...