2016年3月1日 · Here, we report an EGF/EGFR/fructose-1,6-bisphosphate (F1,6BP) signaling axis in TNBC cells that increases lactate production, which promotes immune evasion. Our findings provide a rationale for combining EGFR tyrosine kinsase inhibitor, gefitinib, with glycolysis inhibitor, 2-DG, as a potential therapeutic strategy for TNBC.

2014年7月7日 · Here we show that EGFR signaling plays an important role in aerobic glycolysis in EGFR-mutated LAD cells. EGFR-tyrosine kinase inhibitors (TKIs) decreased lactate production, glucose consumption, and the glucose-induced extracellular acidification rate (ECAR), indicating that EGFR signaling maintained aerobic glycolysis in LAD cells.

2023年11月5日 · 表皮生长因子受体（epidermal growth factor receptor, EGFR）扩增、过表达和致病突变在GBM中常见。 值得注意的是， EGFR-vIII突变在没有任何配体刺激的情况下具有组成型酪氨酸激酶活性。 伴有EGFR扩增和EGFR-vIII突变的GBM与更高恶性程度相关。 虽然过度激活的EGFR通路在脂肪生成和胆固醇摄取中发挥作用，但EGFR通路是否参与脂肪酸代谢和能量生成尚不清楚。 细胞代谢的重编程是肿瘤发生的另一个病理标志，支持肿瘤细胞对能量的高需求， …

2018年11月29日 · 建立重组人表皮生长因子(recombinant human epidermal growth factor,rh EGF)生物学活性的检测方法，并与其他4种常见显色方法进行比较。方法参考《中国药典》三部(2015版)附录3528中3T3细胞/MTT显色法，建立rh EGF生物学活性的检测方法，

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.

2011年4月20日 · Here we focus on the interaction between two engineered epidermal growth factor (EGF) mutants and the EGF receptor (EGFR), a model member of the RTK superfamily. We found that EGF mutants with faster kinetic on-rates stimulate increased EGFR activation compared to wild-type EGF.

此外，通过检测细胞外酸化率（ECAR）和耗氧率（OCR）来反映黑色素瘤细胞的糖酵解代谢情况。通过蛋白质印迹测试与凋亡、糖酵解和EGFR/STAT3信号传导相关的蛋白的表达。随后，用EGF或Colivelin处理黑色素瘤细胞，以进一步阐明KIF22对EGFR/STAT3信号传导的调节作用。

2003年3月10日 · The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-α, and the neuregulins.

2023年11月7日 · In addition, the glycolysis metabolism of melanoma cells was reflected by detecting Extracellular Acidification Rates (ECAR) and Oxygen Consumption Rates (OCR). The expression of proteins related to apoptosis, glycolysis and EGFR/STAT3 signaling was tested by …

EGF receptor endocytic traffic can regulate signaling and cell survival. Signaling from activated EGFR occurs at the endosome as well as the cell surface. Endocytosis can have positive and negative effects on signaling and tumorigenesis. EGFR traffic promoted by antineoplastic therapy is important in tumor resistance.