2018年4月1日 · Src dependent phosphorylation of EGFR enhances EGF induced mitogenic responses [1, 2, 7] but mutation of the Src phosphorylation site (Y845F) on EGFR does not …

Receptor tyrosine kinases (RTKs), such as the EGF receptor family, and adhesion molecules, such as integrins, have historically been viewed to have distinctly separable roles in the cell. In …

2015年12月8日 · The current studies have established the crucial contribution of Src to EGFR signaling by priming substrates for enhanced phosphorylation by EGFR. Src is thus able to …

肿瘤表皮生长因子受体(EGFR)是一个170KDa的跨膜糖蛋白受体酪氨酸激酶，由表皮生长因子激活，影响细胞的生长和分化。 EGFR 家族又称为EGFR酪氨酸激酶家族，由4个不同的受体酪氨 …

2017年8月30日 · In this study, we investigated (1) whether Src mediates epidermal growth factor receptor (EGFR) transactivation; (2) if ERK1/2, PI3Kδ/Akt and NF-κB are signaling effectors …

1999年3月5日 · We report that EGFR signaling, in response to EGF binding, stimulates SRC kinase activity which is required for CHC phosphorylation and clathrin redistribution to the cell …

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the …

2021年1月8日 · EGFR that is constitutively activated in the majority of GBM causes YTHDF2 overexpression through the EGFR/SRC/ERK pathway. EGFR/SRC/ERK signaling …

1994年11月1日 · In this report, we demonstrate EGF-dependent activation of src-family tyrosine kinases in NIH3T3 cells overexpressing the human EGF receptor. Activation is rapid (< 1 min) …

表皮生长因子受体 (Epidermal growth factor receptor，EGFR) 是受体酪氨酸激酶家族 (receptor tyrosine kinase family，RTK) 中第一个被发现的原型成员。 它被细胞外环境中的各种配体激活 …