Transcription factor EGR2 controls homing and pathogenicity of T
2023年7月13日 · EGR2 was significantly elevated in myelin-reactive CD4 + T cells from patients with multiple sclerosis and mice with autoimmune neuroinflammation. The EGR2 …
Egr2-dependent gene expression profiling and ChIP-Seq reveal …
2013年10月1日 · We recently reported that early growth response gene 2 (Egr2) is a critical transcription factor for the induction of anergy in vitro and in vivo, which was identified based …
Transcriptional regulator early growth response gene 2 (Egr2) …
Conditional Egr2 deletion in peripheral T cells abolishes induced expression of DGK-α and other anergy genes and restores Ras/MAPK signaling, IL-2 production, and proliferation upon …
The transcription factor EGR2 controls homing and pathogenicity …
EGR2 was significantly elevated in myelin-reactive CD4 + T cells from multiple sclerosis patients and mice with autoimmune neuroinflammation. The EGR2 transcriptional program was …
南京医科大学肖明和盛呈雨课题组发现Egr2通过调控髓鞘形成参与 …
Egr2是隔离饲养小鼠社会行为障碍的潜在靶基因 为了探索SI导致的上述行为改变潜在的分子机制，研究人员对GH组和SI组小鼠mPFC样本进行RNA测序。
The transcription factor EGR2 is indispensable for tissue
2021年11月19日 · Using cell-specific ablation of Egr2 and mixed bone marrow (BM) chimeric mice, we show that cell-intrinsic EGR2 is indispensable for the tissue-specific identity of …
The epigenetic pioneer EGR2 initiates DNA demethylation in ...
2021年3月10日 · Our findings reveal an essential role for EGR2 as epigenetic pioneer in human MO and suggest that active DNA demethylation can be initiated by the TET2-recruiting TF …
The transcription factor EGR2 is the molecular linchpin connecting ...
2020年11月1日 · We identified the TF, early growth response 2 (EGR2), bridging the early transient and late stable gene expression program of polarization. EGR2 is a direct target of IL …
Early growth response 2 and Egr3 are unique regulators in …
Early growth response genes are family of transcription factors comprising of four members, Egr1, Egr2, Egr3 and Egr4. All of which contain three cyc2-His2 zinc fingers. Initially, Egr2 function …
Early Growth Response Gene-2 (Egr-2) Regulates the …
2011年4月14日 · It has been shown that Egr-2 deficiency results in impaired NKT cell development and defective positive selection of T cells. Here we investigated the development …