2025年3月6日 · 研究表明，人类纤维化的 MASH 肝脏中与低密度脂蛋白胆固醇相关的全基因组关联研究（GWAS）位点 EH-domain-结合蛋白 1（EHBP1）减少以及EHBP1 的功能缺失能够促进 MASH 纤维化水平。

2025年2月26日 · We show that human fibrotic MASH livers have decreased EH-domain-binding protein 1 (EHBP1), a genome-wide association study (GWAS) locus associated with low-density lipoprotein (LDL) cholesterol, and that EHBP1 loss- and gain-of-function increase and decrease MASH fibrosis in mice, respectively.

EHD1 and EHD2 interact with an actin-binding protein, EHBP1, through the NPF motif found within EHBP1 (43). Our model suggests that the ferlins and EHBP1 may compete for EHD binding to regulate the complex process of exit from the endocytic recycling compartment, translocation to the plasma membrane, and reorganization of the actin cytoskeleton ...

2011年2月1日 · Functionally, both EHBP1 and EHD2 have been linked to internalization of receptors such as transferrin and GLUT4, potentially by linking clathrin-dependent endocytosis to filamentous actin via the EHBP1 CH domain [37].

2004年3月12日 · Here we identified two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton. EHD2 contains an N-terminal P-loop and a C-terminal EH …

Here we identified two novel proteins denoted EH domain protein 2 (EHD2) and EHD2-binding protein 1 (EHBP1) that link clathrin-mediated endocytosis to the actin cytoskeleton. EHD2 contains an N-terminal P-loop and a C-terminal EH domain …

Functionally, both EHBP1 and EHD2 have been linked to internalisation of receptors such as transferrin and GLUT4, potentially by linking clathrin-dependent endocytosis to filamentous actin via the EHBP1 CH domain [37].

2025年2月26日，来自美国西奈山医学院肝病研究中心的 蔡碧双 团队（第一作者为马方琳）在 Cell Metabolism 上在线发表了文章 EHBP1 Suppresses Liver Fibrosis in Metabolic Dysfunction- associated Steatohepatitis。 在该研究中，研究人员 在肝细胞上发现膜泡运输蛋白EHBP1抑制细胞膜表面LDL受体 （LDLR） 的表达及LDLR 调控的低密度脂蛋白 （LDL） 的摄取，从而减少TAZ的表达及其调控的肝纤维化。 在该研究中， 团队首先评估了EHBP1基因的与胆固醇调节 …

Ubiquitous expression in ovary (RPKM 15.6), fat (RPKM 14.1) and 25 other tissues. 该基因编码 Eps15 同源结构域结合蛋白。 编码的蛋白质可能在内吞运输中发挥作用。 该基因中的单核苷酸多态性与侵袭性前列腺癌有关。 交替剪接导致多个转录本变体。 [RefSeq 提供，2010 年 2 月] This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking.

Here, we report that an Eps15 homology (EH) domain-containing protein, EHD1, controls the normal perinuclear localization of GLUT4-containing membranes and is required for insulin-stimulated recycling of these membranes in cultured adipocytes.