Molecular interplay between EIF4 family and circular RNAs in …
2023年9月5日 · Recent research has shown that circRNAs work with EIF4s to promote translational sloppiness and oncogenic genetic processes, which can influence the malignant …
Dynamically regulated two-site interaction of viral RNA to ... - Nature
2023年8月28日 · The IRES from encephalomyocarditis virus (EMCV) interacts with eukaryotic translation initiation factor 4 G (eIF4G), recruiting the ribosomal subunit for translation. Here, …
eIF4E-independent translation is largely eIF3d-dependent
2024年8月6日 · We study here how mRNAs are translated in an eIF4E1-independent manner by blocking eIF4E1 using a constitutively active version of eIF4E-binding protein (4E-BP). Via …
An accurately preorganized IRES RNA structure enables eIF4G …
2016年8月15日 · As a first step toward assembling ribosomes, the EMCV IRES element is designed to directly interact with HEAT-1, the first of the three HEAT domains of eIF4G 13, 14. …
蛋白质翻译的起始阶段（二） - 知乎 - 知乎专栏
内部核糖体进入位点（IRES），是在病毒mRNA中首先发现的一种顺式元件，可以借助IRES 反式作用因子（ITAF），将核糖体募集到病毒mRNA中的特定起始密码子，从而允许非帽依赖的翻 …
IRES interaction with translation initiation factors: functional ...
Remarkably, IRES mutants severely affected in their interaction with eIF4B showed a mild reduction in IRES activity when tested in the context of a bicistronic expression vector in …
eIF4A在帽依赖和IRES介导的翻译起始中的作用
Additionally, eIF4A engages in complex and close interactions with other eukaryotic initiation factors, playing a key role in both cap-dependent and IRES-mediated translation initiation …
IRES interaction with translation initiation factors: Functional ...
2001年9月25日 · Translation initiation promoted by picornavirus internal ribosome entry site (IRES) elements is dependent on the association of specific IRES sequences to the initiation …
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G
2018年2月13日 · One such strategy is the use of internal ribosome entry site (IRES) elements, which circumvent the requirement for some eukaryotic initiation factors (eIFs). Much effort has …
Functional diversity of the eukaryotic translation initiation factors ...
2005年7月1日 · Protein synthesis in eukaryotic cells is fundamental for gene expression. This process involves the binding of an mRNA molecule to the small ribosomal subunit in a group …